| Project/Area Number |
16K19904
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 蛍光プローブ / 分子イメージング / ゲノム医療 |
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| Outline of Final Research Achievements |
Fluorescence imaging has now attracted a great interest as a new method of real-time cancer diagnosis. The aim of this study is to evaluate the diagnostic performance of the probe for breast cancer. We investigated theγGlu-HMRG activity using the specimens obtained by core needle biopsy (CNB) or vacuum-assisted breast biopsy (VAB).
The differential ability between cancer and benign was 70% in sensitivity and 61% in specificity. It was possible to distinguish between invasive cancer and benign tumor, while differential diagnosis between invasive cancer and non-invasive cancer, or benign tumor and non-invasive cancer was difficult.In addition, ER negative, ki67 high value, and HER2 type had high fluorescence intensity in invasive cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
本蛍光プローブを用いることにより、検体採取後直ちに目的とする部位（癌組織）が含まれていることを確認することができる。これはサンプリングエラーを防ぐことにつながり、不要な再生検を防ぐことができる。また、治療方針決定に有用なサブタイプやバイオマーカー等の推定も可能となり、早期に治療を開始可能となることが期待される。
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