| Project/Area Number |
16K19926
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
Takeda Koki 大阪大学, 医学部附属病院, 医員 (20768965)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗原提示細胞 / 腸管粘膜固有層 / マクロファージ / CD14 / CD13 / phagocytosis / 腸管免疫 |
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| Outline of Final Research Achievements |
As a result of May-Giemsa staining, both CD 14 + Mφ and CD 14-Mφ morphologically were cells with relatively small N / C ratio with vesicles inside. In the Phagocytosis assay, phagocytotic capacity of CD14 + Mφ and CD14-Mφ was slight compared to peripheral blood monocytes, but CD14-Mφ had lower phagocytic ability than CD14 + Mφ. In Crohn's disease, CD14 - Mφ decreased in inflamed intestinal tract, CD 14 + Mφ increased in inflamed state intestinal tract. From the above results, it is suggested that CD14 - Mφ has a weak phagocytic ability and is attenuated in inflammatory bowel disease, so it may have the function of immune tolerance.
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