Identification of bone marrow-derived involved in pancreatic cancer progression and establishment of a new therapy
| Project/Area Number |
16K19937
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
Iwamoto Chika 九州大学, 医学研究院, 特任助教 (10752842)
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| Research Collaborator |
OHUCHIDA Kenoki
OKUMURA Takashi
ENDO Sho
KOIKAWA Kazuhiro
TAKESUE Shin
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵癌 / 浸潤 / 膵臓癌 / 転移 / 癌 |
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| Outline of Final Research Achievements |
In breast cancer, a subset of stromal cells was descended from bone marrow (BM)-derived cells. While BM-derived cells seem to be involved in remodeling of microenvironment and tumor progression in pancreatic cancer, this mechanism remains unknown. We aimed to investigate an association between pancreatic cancer progression and BM-derived cells.
The engraftment of BM-derived GFP+ cells was detected in recipients’ peripheral blood, BM, pancreas, liver, and ascites. In recipients’ pancreas, GFP+ cells were accumulated around ADM/PanIN and at invasive front. Invasive capability of cancer cells co-cultured with BM-derived cells significantly increased compared to the control. The present data also suggest that BM-derived cells is involved in infiltration of cancer cells.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo1802018
Author(s)
Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M.
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Journal Title
Cancer Letters
Volume: 412
Pages: 143-154
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Autophagy is required for activation of pancreatic sstellate cells, associated with pancreatic cancer progression and promotes growth of pancreatic tumors in mice.2017
Author(s)
Endo S, Nakata K, Ohuchida K, Takesue S, Nakayama H, Abe T, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M.
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Journal Title
Gastroenterology
Volume: 印刷中
Issue: 6
Pages: 1492-1506
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells.2017
Author(s)
Okumura T, Ohuchida K, Sada M, Abe T, Endo S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Oda Y, Hashizume M, Nakamura M.
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Journal Title
Oncotarget
Volume: 8
Issue: 11
Pages: 18280-18295
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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