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Metabolic remodeling of glioblastoma by vascular endothelial growth factor (VEGF) inhibitor Bevacizumab

Research Project

Project/Area Number 16K20010
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKobe University

Principal Investigator

Tanaka Hirotomo  神戸大学, 医学研究科, 医学研究員 (10569239)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsglioblastoma / VEGF / metabolic / glioma / bevacizumab / グリオーマ / メタボロ‐ム解析 / ベバシズマブ / metabolome
Outline of Final Research Achievements

In vivo experiment, citrate was increased, and pyruvate, succinate, fumarate, malate, and glutamine were decreased by Bevacizumab treatment in the tumors. By the treatment of Glutaminase(GLS) inhibitor, citrate, pyruvate, succinate, fumarate, malate, glutamine, and lactate were decreased in the tumors. By the treatment of both Bevacizumab and GLS inhibitor, citrate, pyruvate, succinate, fumarate, malate, glutamine, and lactate were decreased. Dual treatment induced significant inhibition of TCA cycle. In vitro experiment, U87 cell proliferation was inhibited by dual treatmet (bevacizumab + GLS inhibitor). Finally, in vivo experiment, Bevacizumab treatment had significant longer survival than control. However, dual treatment (Bevacizumab and GLS inhibitor) did not have longer survival than Bevacizumab alone.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] Embryonal brain tumor with unknown primary lesion and massive cerebrospinal fluid dissemination: a case report2018

    • Author(s)
      Hirotomo Tanaka1), Daisuke Yamamoto3), Mitsuru Ikeda1), Masashi Morikawa1), Kayo Ueda2), Takashi Sasayama3), Eiji Kohmura
    • Journal Title

      Journal of clinical neuroscience

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 39-Year-Old Female with cerebellar tumor, cervical cord lesion and visual disturbance2018

    • Author(s)
      Hirotomo Tanaka1), Daisuke Yamamoto1), Katsu Mizukawa1), Akiyasu Kanamori2), Norio Chihara3), Ryosuke Matsuoka4), Shigeo Hara4), Takanori Hirose4), Takashi Sasayama1), Eiji Kohmura1
    • Journal Title

      Brain Pathology

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid tumor growth with glial differentiation of central neurocytoma after stereotactic radiosurgery2016

    • Author(s)
      42.Tanaka H, Sasayama T, Yamashita H, Hara Y, Hayashi S, Yamamoto Y, Fujita Y, Okino T, Mizowaki T, Yamaguchi Y, Tanaka K, Kohmura E
    • Journal Title

      J Clin Neurosci.

      Volume: 31 Pages: 188-92

    • DOI

      10.1016/j.jocn.2016.01.036

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor-Associated Macrophages Associate with Cerebrospinal Fluid Interleukin-10 and Survival in Primary Central Nervous System Lymphoma (PCNSL)2015

    • Author(s)
      Sasayama T, Tanaka K, Mizowaki T, Nagashima H, Nakamizo S, Tanaka H, Nishihara M, Mizukawa K, Hirose T, Itoh T, Kohmura E
    • Journal Title

      Brain Pathol.

      Volume: Aug 28 Issue: 4 Pages: 1-9

    • DOI

      10.1111/bpa.12318

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 広範な髄腔内播種を認めた中枢神経胎児性腫瘍の1例2017

    • Author(s)
      田中宏知、森川雅史、池田充、岩橋洋文、井村隼、上田佳世、山本大輔、篠山隆司、甲村英二
    • Organizer
      第35回日本脳腫瘍病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多彩な組織像を呈した悪性グリオーマの1例2017

    • Author(s)
      田中宏知、井村隼、岩橋洋文、上田佳世、池田充、森川雅史、篠山隆司
    • Organizer
      第112回近畿脳腫瘍病理検討会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 髄膜腫術後に生じた静脈性梗塞の検討2017

    • Author(s)
      田中宏知、井村隼、池田充、森川雅史、甲村英二
    • Organizer
      第22回日本脳腫瘍の外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Survival benefit of antiepileptic drugs in patients with glioblastoma2017

    • Author(s)
      Hirotomo Tanaka, Takashi Sasayama, Masamitsu Nishihara, Masashi Morikawa, Mitsuru Ikeda, Kazuhiro Tanaka, Eiji Kohmura
    • Organizer
      22nd annual scientific meeting and education day of the society for neuro-oncology
    • Related Report
      2017 Annual Research Report
  • [Presentation] 1.5Tおよび3.0TMRAにおける生理学的静脈洞描出の頻度2016

    • Author(s)
      田中宏知、森川雅史、池田充、岩橋洋文、甲村英二
    • Organizer
      日本脳神経外科学会 第75回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 未破裂脳動脈瘤クリッピング術における術中64列CTアンギオの画質向上の工夫2016

    • Author(s)
      森川雅史、池田充、田中宏知、岩橋洋文、甲村英二
    • Organizer
      日本脳神経外科学会 第75回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
  • [Presentation] ViewSiteチューブリトラクターを用いたナビゲーションガイド下脳腫瘍生検術2016

    • Author(s)
      田中宏知、森川雅史、池田充、岩橋洋文、甲村英二
    • Organizer
      第21回 日本脳腫瘍の外科学会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 著明な髄腔内播種を認めた脳腫瘍の1例2016

    • Author(s)
      田中宏知、岩橋洋文、池田充、森川雅史
    • Organizer
      第110回 近畿脳腫瘍病理検討会
    • Place of Presentation
      大阪
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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