moleculs related to fatty acid metabolism in glioma
Project/Area Number |
16K20016
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
|
Research Institution | Saga University |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | glioma / CPT1C / FASN / metformine / metformin / hypoxia / 脂肪酸代謝 / グリオーマ / 脂肪酸 / p53 |
Outline of Final Research Achievements |
We study fatty acid synthase (FASN) and carnitine palmitoyltransferase 1C(CPT1C) related to fatty acid metabolism in human gliomas.We performed an expression of mRNA by using Real-time PCR.In human glioma cell lines, Both mRNA of FASN and CPT1C increased in glucose-free medium. Metformine is known a drug with effect of anticancer agent.In the medium administrated to metformine,mRNA of CPT1C increased in the human glioma cell lines.
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Report
(3 results)
Research Products
(1 results)