moleculs related to fatty acid metabolism in glioma

Research Project

Project/Area Number	16K20016
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neurosurgery
Research Institution	Saga University
Principal Investigator	Wakamiya Tomihiro 佐賀大学, 医学部, 客員研究員 (50773769)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	glioma / CPT1C / FASN / metformine / metformin / hypoxia / 脂肪酸代謝 / グリオーマ / 脂肪酸 / p53
Outline of Final Research Achievements	We study fatty acid synthase (FASN) and carnitine palmitoyltransferase 1C(CPT1C) related to fatty acid metabolism in human gliomas.We performed an expression of mRNA by using Real-time PCR.In human glioma cell lines, Both mRNA of FASN and CPT1C increased in glucose-free medium. Metformine is known a drug with effect of anticancer agent.In the medium administrated to metformine,mRNA of CPT1C increased in the human glioma cell lines.

Report

(3 results)