• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The antitumor effect of 17-DMAG combined with Doxorubicin in osteosarcoma cells.

Research Project

Project/Area Number 16K20063
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionOita University

Principal Investigator

Iwasaki Tatsuya  大分大学, 医学部, 助教 (30769427)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨肉腫 / Heat shock protein 90 / MET / アドリアマイシン / Heat shock protein / Immunological Cell Death / heat shock protein / ドキソルビシン / HSP90阻害剤
Outline of Final Research Achievements

Recently, inhibition of heat shock protein 90 (HSP90), a type of molecular haperone, has attracted attention as an important treatment target, because HSP90 has the unction of stabilizing the structure of cancer-associated proteins. When we mprehensively analyzed the gene expression of osteosarcoma cell lines, we scertained that the expression of MET, a type of HSP90 client protein, was niversally elevated. MET is a tyrosine kinase receptor that may possibly acquire proliferation and anti-apoptotic ability through activation from the MET protein constructed by HSP90. So, in this study, we verified the changes in MET signal activity and anti-tumor effect by administering the HSP90 inhibitor 17-DMAG to osteosarcoma cells.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Interaction between human osteosarcoma and mesenchymal stem cells via an interleukin-8 signaling loop in the tumor microenvironment.2018

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Cell Commun Signal.

      Volume: 16 Pages: 13-13

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-181c prevents apoptosis by targeting of FAS receptor in Ewing's sarcoma cells.2018

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Cancer Cell Int.

      Volume: 18 Pages: 37-37

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells.2017

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Int J Oncol.

      Volume: 51 Pages: 1842-1850

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨肉腫細胞における17-DMAGによるMET発現抑制と腫瘍増殖能の解析2017

    • Author(s)
      河野正典
    • Organizer
      第50回日本整形外科学会骨・軟部腫瘍学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨肉腫の微小環境におけるIL-8 signalの意義2017

    • Author(s)
      河野正典
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi