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Study of cardiotonic action of pland-derived flavonoid, quercetin and its molecular mechanism

Research Project

Project/Area Number 16K20103
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionSapporo Medical University (2019)
Kyushu University (2016-2018)

Principal Investigator

Hayamizu Kengo  札幌医科大学, 医学部, 研究員 (70444833)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsクエルセチン / フラボノイド / 強心作用 / カルシウムトランジェント / 陽性変力作用 / タマリキセチン / イソラムネチン / カルシウムジェント / 薬理学
Outline of Final Research Achievements

The plant-derived flavonoid, quercetin (QCT), has many biological actions, including anti-tumor effects and cardioprotective effects, resulting from its antioxidant and anti-inflammatory effects.
In this study, the aim of our study was to find the direct effects of QCT on cardiac function to explore other unknown mechanisms underlying its actions exerted on the cardiovascular system.Our study demonstrated that QCT and its metabolite have a potent cardiotonic action through the in vivo and in vitro experiment, through digitalis-like enhancement of Calcium transient in cardiomyocytes in addition to antioxidant and anti-inflammatory effects. We presented our findings at the international conference and published in the refereed journal.

Academic Significance and Societal Importance of the Research Achievements

本研究は、クエルセチンとその代謝物がこれまでに知られている抗酸化作用や抗炎症作用に加えインビボにおいて強力な強心作用をもつことを証明し、その少なくとも一部はジギタリス様心筋細胞カルシウムトランジェント増強によっていることを証明することができた。
これは、クエルセチンが心臓血管疾患に対してこれまで考えられてきたよりさらに有用な効果を持つ可能性を示唆している。心臓血管保護作用を持ちながら、強心作用を持つ薬として心臓血管疾患に対して新たに臨床使用できる可能性を示すことができた。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca 2+ transients2018

    • Author(s)
      Hayamizu Kengo、Morimoto Sachio、Nonaka Miki、Hoka Sumio、Sasaguri Toshiyuki
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 637 Pages: 40-47

    • DOI

      10.1016/j.abb.2017.11.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca2+ transients2018

    • Author(s)
      Kengo Hayamizu, Miki Nonaka , Sachio Morimoto
    • Organizer
      Biophysical Society 62nd Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 九州大学病院 手術部 研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K005694/index.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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