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Elucidation of recurrence mechanism of IgA nephropathy after kidney transplantation from structural analysis of IgA1 O-glycans

Research Project

Project/Area Number 16K20132
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

Nakazawa Shigeaki  大阪大学, 医学部附属病院, 医員 (80759530)

Research Collaborator IMAMURA ryoichi  大阪大学, 医学系研究科, 准教授
Wada yoshinao  大阪府立母子保健総合医療センター, 研究所, 前所長
Iwatani hirotsugu  国立大阪医療センター, 腎臓内科, 部長
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsIgA腎症 / 腎移植 / IgA沈着症 / 0型糖鎖 / O型結合糖鎖
Outline of Final Research Achievements

In O-glycans analysis using MALDI-TOF-MS, GalNAc and Gal content in HR of IgAN recipients were significantly decreased than IgAD donors and healthy donors. However, in all patterns of O-glycans, there was no significant difference between IgAD donors and healthy donors.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] The number of O-linked oligosaccharides per heavy chain of human serum IgA1 is different between IgA nephropathy and IgA deposition2017

    • Author(s)
      Shigeaki Nakazawa
    • Organizer
      第105回 日本泌尿器科学会総会
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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