Elucidation of recurrence mechanism of IgA nephropathy after kidney transplantation from structural analysis of IgA1 O-glycans
| Project/Area Number |
16K20132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
IMAMURA ryoichi 大阪大学, 医学系研究科, 准教授
Wada yoshinao 大阪府立母子保健総合医療センター, 研究所, 前所長
Iwatani hirotsugu 国立大阪医療センター, 腎臓内科, 部長
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | IgA腎症 / 腎移植 / IgA沈着症 / 0型糖鎖 / O型結合糖鎖 |
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| Outline of Final Research Achievements |
In O-glycans analysis using MALDI-TOF-MS, GalNAc and Gal content in HR of IgAN recipients were significantly decreased than IgAD donors and healthy donors. However, in all patterns of O-glycans, there was no significant difference between IgAD donors and healthy donors.
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Report
(3 results)
Research Products
(1 results)
