| Project/Area Number |
16K20155
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
KATAOKA TOMOYA 名古屋市立大学, 大学院医学研究科, 助教 (20737928)
|
|---|
| Research Collaborator |
FUKAMOTO Ayako 名古屋市立大学, 薬学部, 学部生
ASANO Gakuto 名古屋市立大学, 薬学部, 学部生
HIDAKA Junya 名古屋市立大学, 薬学部, 学部生
SUZUKI Jun 名古屋市立大学, 薬学部, 学部生
HOTTA Yuji 名古屋市立大学, 大学院薬学研究科, 講師 (90637563)
MAEDA Yasuhiro 名古屋市立大学, 大学院薬学研究科, 講師 (60275146)
KIMURA Kazunori 名古屋市立大学, 大学院医学研究科, 教授 (00423848)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | 睡眠障害 / 勃起障害 / テストステロン / 睡眠不足 / 性機能障害 |
|---|
| Outline of Final Research Achievements |
We made sleep disorder model rats and investigated the effect on the sexual function. Normally, rats were raised under a light / dark cycle every 12 hours, but a chronic jet lag (CJL) treatment was performed which performed a process of advancing the light / dark cycle by 8 hours every 2 days. The ICP/MAP ratio was 0.81 ± 0.12 at 1 week after CJL treatment, and no change was observed. In addition, after 2 weeks it was 0.73 ± 0.12, which did not change, but after 4 weeks a significant decrease of 0.35 ± 0.05 was observed. When the expression of eNOS and phosphorylated eNOS was examined by western blotting method using the corpus cavernosum of rats 4 weeks after CJL treatment, significant decreases were observed in the CJL treatment group.
|
