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The effect of self-sampled HPV testing on participation in cervical cancer screening

Research Project

Project/Area Number 16K20199
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionNagasaki University

Principal Investigator

ABE Shuhei  長崎大学, 病院(医学系), 助教 (50549590)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords子宮頸がん / 自己採取型HPV検査 / 受診率向上 / 子宮頸癌 / 子宮頸がん検診 / 受診率 / 自己採取 / HPV検査 / 産科婦人科学 / 婦人科腫瘍学 / 検診
Outline of Final Research Achievements

Non-attenders, who do not regularly attendance to the cervical cancer screening, are high-risk group of cervical cancer onset. Because of attendance to screening is low in Japan, making improvement of attendance were needed. Self-sampling devices for human papillomavirus (HPV) testing can be a useful method to make improvement of attendance to cancer screening. To determine whether self-sampling devices improves attendance to cervical cancer screening, 2,986 non-attenders aged 20-49 years in distant Island were selected and invited to be part of this study. Response rate (attendance to screening and/or returning kit) was 76% (n=95/125) in the self-sampling group. In self-sampling group, only 50% (n=5/10) HPV-positive women attended to follow-up cytology. In conclusion, self-sampling device possibly will be making improvement of attendance to cervical cancer screening.

Academic Significance and Societal Importance of the Research Achievements

本研究に同意頂いた子宮頸がん検診未受診者249例の中から、子宮頸部細胞診判定がSCCの1例を同定し得た。離島が多く存在する長崎県において、自己採取HPV検査を運用することにより、遠隔地在住の子宮頸がん検診未受診者の受診率向上が期待できる。自己採取型HPV-DNA検査は、子宮頸がん検診未受診者の検診受診率向上に有効と考えられた。本研究は今後、次世代シークエンス法を用いたexsome解析およびメチル化アレイ解析を行うことで、より詳細な子宮頸癌発症に関与する宿主側要因の同定に連なることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Circulating levels of pregnancy-associated, placenta-specific microRNAs in pregnant women with placental abruption2017

    • Author(s)
      Miura K, Higashijima A, Murakami Y, Fuchi N, Tsukamoto O, Abe S, Hasegawa Y, Miura S, Masuzaki H
    • Journal Title

      Reproductive Science

      Volume: 24 Issue: 1 Pages: 148-155

    • DOI

      10.1177/1933719116653837

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population.2016

    • Author(s)
      Miura K, Mishima H, Yasunami M, Kaneuchi M, Kitajima M, Abe S, Higashijima A, Fuchi N, Miura S, Yoshiura KI, Masuzaki H.
    • Journal Title

      J Hum Genet.

      Volume: 61(9) Issue: 9 Pages: 793-796

    • DOI

      10.1038/jhg.2016.50

    • NAID

      40020938176

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 子宮頸がん検診の受診率向上に向けた自己採取型HPV検査キットの有用性に関する検討2017

    • Author(s)
      阿部 修平、三浦 清徳、金内 優典、増崎 英明
    • Organizer
      第69回日本産科婦人科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Remarks] 長崎大学医学部産婦人科

    • URL

      http://www.med.nagasaki-u.ac.jp/gyneclgy/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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