| Project/Area Number |
16K20215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 精子形成 / PI3K / 精巣組織培養 / IVA / 人為的活性化 / 精巣IVA |
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| Outline of Final Research Achievements |
The purpose of this study was to regenerate spermatogenesis by activating PI3K / Akt signal of residual spermatogonia in patients with spematogenesis dysfunction and to develop a treatment for spematogenesis dysfunction. Human testis were used to verify the function and normality of sperm obtained by activation of PI3K / Akt signal in vitro culture of testis tissue. Spermatogenesis was induced in testicular tissues of azoospermia patients, and functional analysis and normality of the obtained spermatozoa were examined. From the above results, it was revealed that in patients with non - obstructive azoospermia, there are a variety of causes of disease, some patients may be activated but others may not be activated.
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