| Project/Area Number |
16K20220
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
Yoo Saha 大阪医科大学, 医学部, 助教 (80625674)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 子宮頸癌 / HPV / エキソソーム / インテグレーション / ＣＩＮ / ヒトパピローマウィルス |
|---|
| Outline of Final Research Achievements |
We followed Japanese patients with CIN1-2 for a mean follow up period of 35.1 months. We detected HPV DNA in cervical samples by PCR method. Over the follow up period, 13 (16.3%) lesions progressed to CIN3, while 55 lesions (68.8%) disappeared and 12 (15.0%) lesions persisted. The genotypes in which lesions progressed were type 16,31,33,35,52,56,respectively. And We extracted exosome from cervical cancer cell lines.We will analyze the association between HPV genotype and exosome.
|
