An association between HPV integration and exosome
| Project/Area Number |
16K20220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
Yoo Saha 大阪医科大学, 医学部, 助教 (80625674)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮頸癌 / HPV / エキソソーム / インテグレーション / ＣＩＮ / ヒトパピローマウィルス |
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| Outline of Final Research Achievements |
We followed Japanese patients with CIN1-2 for a mean follow up period of 35.1 months. We detected HPV DNA in cervical samples by PCR method. Over the follow up period, 13 (16.3%) lesions progressed to CIN3, while 55 lesions (68.8%) disappeared and 12 (15.0%) lesions persisted. The genotypes in which lesions progressed were type 16,31,33,35,52,56,respectively. And We extracted exosome from cervical cancer cell lines.We will analyze the association between HPV genotype and exosome.
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Report
(3 results)
Research Products
(1 results)
