Research Project
Grant-in-Aid for Young Scientists (B)
The SOD activity was examined in the eosinophilic and non-eosinophilic CRS with nasal polyps as well as control sinus mucosa. The results can be summarized as follows: i) the SOD activity of the CRS groups was significantly decreased compared with that of the controls; ii) immunostaining of both CuZnSOD and MnSOD of the eosinophilic group was significantly decreased compared with that of the non-eosinophilic and control groups; iii) CuZnSOD mRNA of the eosinophilic group was significantly decreased compared with that of the control; iv) MnSOD mRNA of the eosinophilic group was significantly decreased compared with those of the non-eosinophilic and control groups. In conclusion, a disrupted balance between the oxidant generation mediated by recruited eosinophils and the oxidant defense system of SOD is suggested to play an important role in the formation and exacerbations of CRS with nasal polyps.
All 2017 2016
All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results)
Ear Nose Throat J.
Volume: 96(12) Pages: 469-476
耳鼻咽喉科臨床 補冊
Volume: (0912-1870)補冊150 Pages: 136-136
