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New treatment strategy in eosinophilic rhinosinusitis based on anti-oxidant reaction

Research Project

Project/Area Number 16K20278
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionJuntendo University

Principal Investigator

ONO Noritsugu  順天堂大学, 医学部, 助教 (10433773)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsSuperoxide dismutase / 好酸球性副鼻腔炎 / 鼻茸 / Laser microdissection / リモデリング / SOD / IL-17A
Outline of Final Research Achievements

The SOD activity was examined in the eosinophilic and non-eosinophilic CRS with nasal polyps as well as control sinus mucosa. The results can be summarized as follows: i) the SOD activity of the CRS groups was significantly decreased compared with that of the controls; ii) immunostaining of both CuZnSOD and MnSOD of the eosinophilic group was significantly decreased compared with that of the non-eosinophilic and control groups; iii) CuZnSOD mRNA of the eosinophilic group was significantly decreased compared with that of the control; iv) MnSOD mRNA of the eosinophilic group was significantly decreased compared with those of the non-eosinophilic and control groups. In conclusion, a disrupted balance between the oxidant generation mediated by recruited eosinophils and the oxidant defense system of SOD is suggested to play an important role in the formation and exacerbations of CRS with nasal polyps.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Endoscopic endonasal management of recurrent maxillary mucoceles using biliary T-tube stenting.2017

    • Author(s)
      Ono N, Ito S, Homma H, Okada H, Murata J, Ikeda K.
    • Journal Title

      Ear Nose Throat J.

      Volume: 96(12) Pages: 469-476

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 片側性副鼻腔病変を来した疾患の検討2017

    • Author(s)
      濱田 美帆子,小野 倫嗣, 角田 篤信, 池田 勝久
    • Journal Title

      耳鼻咽喉科臨床 補冊

      Volume: (0912-1870)補冊150 Pages: 136-136

    • Related Report
      2017 Annual Research Report
  • [Presentation] 耳下腺 low-grade cribriform cystadenocarcinoma の 1 例2016

    • Author(s)
      小野 倫嗣 、大峡 慎一 、金  隆澤 、角田 篤信 、池田 勝久
    • Organizer
      一般社団法人日本耳鼻咽喉科学会東京都地方部会例会 第213回学術講演会
    • Place of Presentation
      Meiji Seika ファルマ株式会社ビル 地下 1 階ホール・東京都中央区
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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