The therapeutic effect of anti-Angionpoietin 2 antibody in EAU
| Project/Area Number |
16K20294
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
IWATA DAIJU 北海道大学, 医学研究院, 助教 (70374402)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | ぶどう膜炎 / アンジオポエチン2 / 実験的自己免疫性ぶどう膜網膜炎 / アンジオポエチン２ / アンジオポエチン / EAU / 眼免疫学 / 自己免疫性汎ぶどう膜炎 |
|---|
| Outline of Final Research Achievements |
We evaluated the therapeutic effect of anti-Angionpoietin(ANG) 2 antibody(Ab) with Experimental autoimmune uveoretinitis (EAU) mice. Anti-ANG2 Ab was administered twice at day-1 and day7 after EAU induction. In this study, both clinical score and histological score had no significant difference between anti-ANG2 Ab-treated group and untreated group. However, we elucidated the therapeutic effect of combination therapy with anti-ANG2 Ab and anti-VEGF Ab in Endotoxine induced uveitis (EIU) mouse model.
From these results, if EAU mouse is treated with monotherapy with anti-ANG2 Ab, it is necessary to re-consider the amount, timing, and frequency of administration.
On the other hand, this combination therapy may have a potential to treat intraocular inflammation.
|
| Academic Significance and Societal Importance of the Research Achievements |
今回のEAUマウスモデルを用いた検討では抗Ang2抗体単独での十分な炎症抑制効果を示すことはできなかった。しかしながらEIUマウスモデルを用いた検討では抗Ang2抗体と抗VEGF抗体と併用することにより炎症抑制効果が得られる可能性を示すことができた。またその要因の一つとしてNF-κBを介した経路が関与していることが考えられた。このようにAng2阻害薬については投与量や投与間隔、そして他の薬剤との組み合わせをさらに検討することでEAUにおいても有意な治療効果が得られる可能性がある。ひいては将来的な臨床応用につながることも期待できる薬剤と考えられた。
|
Report
(4 results)
Research Products
(51 results)
-
-
-
[Journal Article] HLA-B51 carriers are susceptible to ocular symptoms of Behcet disease and the association between the two becomes stronger towards the east along the silk road: A literature survey.2017
Author(s)
Horie Y, Meguro A, Ohta T, Lee EB, Namba K, Mizuuchi K, Iwata D, Mizuki N, Ota M, Inoko H, Ishida S, Ohno S, Kitaichi N.
-
Journal Title
Ocul Immunol Inflamm.
Volume: 25(1)
Issue: 1
Pages: 37-40
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Invariant natural killer T cells play dual roles in the development of experimental autoimmune uveoretinitis.2016
Author(s)
Satoh M, Namba K, Kitaichi N, Endo N, Kitamei H, Iwata D, Ohno S, Ishida S, Onoe K, Watarai H, Taniguchi M, Ishibashi T,
-
Journal Title
Exp Eye Res.
Volume: 153
Pages: 79-89
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease.2016
Author(s)
Tagawa Y, Namba K, Mizuuchi K, Takemoto Y, Iwata D, Uno T, Fukuhara T, Hirooka K, Kitaichi N, Ohno S, Ishida S
-
Journal Title
Br J Ophthalmol
Volume: 100
Issue: 4
Pages: 473-477
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Choroidal circulation impairment during the anterior recurrence of Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and laser speckle flowgraphy.2016
Author(s)
Takemoto Y, Namba K, Uno T, Mizuuchi K, Iwata D, Ohno S, Hirooka K, Hashimoto Y, Saito W, Sugiyama K, Ishida S.
-
Journal Title
Acta Ophthalmol.
Volume: 94
Issue: 7
Pages: 629-636
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Presentation] Serum levels of epidermal growth factor receptor ligands in patients with non-infectious uveitis2018
Author(s)
1.Fukuhara T, Hamada S, Kitaichi N, Namba K, Kamimura D, Noda K, Kanda A, Iwata D, Mizuuchi K, Murakami M, Ohno S, Ishida S
Organizer
18th International Conference on Behcet’s Disease
Related Report
Int'l Joint Research
-
-
-
[Presentation] Epidemiology of severe, refractory, prolonged ocular sarcoidosis2018
Author(s)
2.Suzuki K, Namba K, Mizuuchi K, Iwata D, Fukuhara T, Hase K, Hamada S, Ohno S, Kitaichi N, Ishihara M, Ishida S
Organizer
36th World Ophthalmology Congress (WOC) 2018
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
