| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We investigated the effect of angiopoietin (Ang) 2 inhibitor treatment on clinical and histological severity of experimental autoimmune uveoretinitis (EAU). 6-week-old C57BL/6 mice were induced EAU. A group of EAU mice was created in which an anti-Ang2 antibody and a non-specific antibody (control) were administered a total of 5 times every 5 days starting the day before EAU induction, the clinical severity was observed over time (every 3-4 days), and the eyes were removed on day 21 to evaluate histopathological severity. The clinical and histopathological severity of the EAU mice was significantly reduced in the anti-Ang2 group compared to the control group (p<0.05).
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