Functional and morphological investigation on the meibomian gland and tarsal plate
| Project/Area Number |
16K20306
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Shirakawa Rika 東京大学, 医学部附属病院, 病院診療医(出向) (30770490)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイボーム腺 / 眼瞼 / 瞼板 / ドライアイ / 眼瞼下垂症手術 / 角膜形状解析 / 動物モデル |
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| Outline of Final Research Achievements |
Clinical observational study about the Meibomian gland and the tarsal plate was conducted. We focused on the postoperative changes of the tarsal plates and the ocular surface after the aponeurotic ptosis surgery for acquired ptosis. Morphology of the Meibomian gland observed by the meibography did not change 6 months after the ptosis surgery. There were significant decrease in anterior average keratometoric corneal power, anterior and posterior corneal astigmatism 6 months postoperatively. We also evaluated efficacy and safety profiles of aponeurotic ptosis surgery for the eye with filtration blebs after trabeculectomy. There was no case of leakage and infection of the blebs and aponeurotic ptosis surgery was effective and could be performed safely even in cases with filtration bleb.
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| Academic Significance and Societal Importance of the Research Achievements |
正常眼およびマイボーム腺機能不全のマイボーム腺の特徴が詳細に分かったことで、ドライアイやマイボーム腺機能不全の診療がより的確に行えるようになった。また、眼瞼下垂症手術に対しての臨床的疑問が解決し、より安全で効果的な手術治療の進歩への貢献が期待できる。眼瞼下垂症術後に角膜形状が変化することが分かったことから、眼瞼下垂症手術後に白内障手術を行う際は、経時的な角膜乱視の変化を観察したうえで慎重に手術時期を検討する必要があると考えられた。
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] Ocular surface alkali injury damages meibomian glands in mice.2017
Author(s)
Mizoguchi S, Iwanishi H, Kokado M, Sumioka T, Parfitt GJ, Xie Y, Arita R, Shirakawa R, Yamanaka O, Okada Y, Jester JV, Saika S.
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Journal Title
Ocul Surf.
Volume: Oct;15(4)
Issue: 4
Pages: 713-722
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Comparison of postoperative course of aponeurotic ptosis surgery in eyes with glaucoma filtration bleb and in eyes after intraocular surgery without bleb2018
Author(s)
Risako Yamamoto, Rika Shirakawa, Tetsuya Toyono, Rei Sakata, Reina Akiyama, Mika Noda, Junko Yoshida, Takashi Miyai,, Tomohiko Usui, Makoto Aihara
Organizer
ARVO2108
Related Report
Int'l Joint Research
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