| Project/Area Number |
16K20334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
YOKOMIZO takehiko
MATSUDA akira
OKUNO toshiaki
KOGA tomoaki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 角膜創傷治癒 / ロイコトリエンB4受容体 / BLT2 / ロイコトリエンB4第二受容体 / 脂質メディエーター / ロイコトリエンB4 / NSAIDs |
|---|
| Outline of Final Research Achievements |
We often use non-steroidal anti-inflammatory drugs(NSAIDs). Past reports show NSAIDs eye drops delay corneal wound healing. But the mechanism was not clear. We focused on the leukotriene B4 receptor2 (BLT2) and 12HHT(BLT2 ligand). The result shows that 12HHT/BLT2 pathway accelerate corneal wound healing. This research make a new eye drops for corneal wound healing.
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| Academic Significance and Societal Importance of the Research Achievements |
日常生活でよく使われる非ステロイド性抗炎症薬(NSAIDs)点眼の副作用のメカニズムの一端を解明した。今後NSAIDs点眼の使用には注意を喚起すると共に、使用に注意を要する症例などがあるため、その情報を発信してゆく。また、新規の角膜治療薬の発見に結びつく研究であり、今後のさらなる研究が必要である。
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