Regulation of leukotriene B4 receptor2(BLT2) accelerates corneal wound by NSAIDs

• Project/Area Number: 16K20334
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Juntendo University
• Principal Investigator: Iwamoto Satoshi 順天堂大学, 医学部, 助教 (10568207)
• Research Collaborator: YOKOMIZO takehiko ; MATSUDA akira ; OKUNO toshiaki ; KOGA tomoaki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 角膜創傷治癒 / ロイコトリエンB4受容体 / BLT2 / ロイコトリエンB4第二受容体 / 脂質メディエーター / ロイコトリエンB4 / NSAIDs

Outline of Final Research Achievements

We often use non-steroidal anti-inflammatory drugs(NSAIDs). Past reports show NSAIDs eye drops delay corneal wound healing. But the mechanism was not clear. We focused on the leukotriene B4 receptor2 (BLT2) and 12HHT(BLT2 ligand). The result shows that 12HHT/BLT2 pathway accelerate corneal wound healing. This research make a new eye drops for corneal wound healing.

Academic Significance and Societal Importance of the Research Achievements

日常生活でよく使われる非ステロイド性抗炎症薬(NSAIDs)点眼の副作用のメカニズムの一端を解明した。今後NSAIDs点眼の使用には注意を喚起すると共に、使用に注意を要する症例などがあるため、その情報を発信してゆく。また、新規の角膜治療薬の発見に結びつく研究であり、今後のさらなる研究が必要である。

Research Products

• [Journal Article] Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2 (2017)
  • Author(s): Iwamoto Satoshi、Koga Tomoaki、Ohba Mai、Okuno Toshiaki、Koike Masato、Murakami Akira、Matsuda Akira、Yokomizo Takehiko
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 13267-13267
  • DOI: 10.1038/s41598-017-13122-8
  • Peer Reviewed / Open Access
• [Presentation] Ocular surfaceと非ステロイド性抗炎症薬 (2019)
  • Author(s): 岩本怜
  • Organizer: 第123回日本眼科学会総会
• [Presentation] NSAIDs cause corneal epithelial damage by inhibition of leukotriene B4 receptor 2 signaling (2016)
  • Author(s): Satoshi Iwamoto
  • Organizer: Association for Research in Vision and Ophthalmology
  • Place of Presentation: Seattle
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] NSAIDsによる角膜創傷治癒遅延の分子メカニズムの解析 (2016)
  • Author(s): 岩本怜
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-07
• [Funded Workshop] ARVO2017 (2017)