| Project/Area Number |
16K20351
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 大網 / リンパシステム / リンパ浮腫 / 乳斑 / リンパ節移植 / 腹部リンパ浮腫モデル / リンパシステム可視化モデル / 大網乳斑 |
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| Outline of Final Research Achievements |
Lymphedema is a chronic disease and there is no established treatment for complete recovery. The omentum is rich in lymphatic system, which has a large amount of lymphoreticular structure called a milky spot. We examined the lymphatic network formation by transplantation of milk spots. We examined the omentum of human cadavar. In the experiments on abdominal lymphedema model mice prepared for this study, significant lymphatic system reconstruction was not achieved by transplantation of nonvascularized milk spots, but was achieved by vascularized lymphnode transfer. Furthermore, scar tissue around lymph nodes might play a significant role in the lymphatic network formation.
The existence of blood flow is important for the reconstruction of the lymphatic system, and further study of controlling the fibrosis is necessary.
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| Academic Significance and Societal Importance of the Research Achievements |
癌の治療において、手術でリンパ節をとったり、放射線治療をおこなったりすると、リンパの流れが悪くなって手足がむくむ状態が一生続く、いわゆるリンパ浮腫という病気になることがあります。大変日常生活に支障をきたす病気ですが、完治に至る治療法はまだ確立されておりません。リンパというものに対してまだまだ基礎的な研究が必要とされております。本研究は、人間のお腹の中にある大網というリンパが豊富な組織に着目し、リンパ浮腫の治療法開発の下地となるような基礎的実験を行なっております。
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