Therapeutic effectiveness of human bone marrow mesenchymal stem cell transplantation in a rat model of crush Injury

• Project/Area Number: 16K20389
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Osaka University
• Principal Investigator: Hisatake Matsumoto 大阪大学, 医学系研究科, 招へい教員 (70644003)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: クラッシュ症候群 / 骨髄由来間葉系幹細胞 / 幹細胞移植 / 再生医療 / 骨髄由来間葉系幹細胞移植 / 集中治療医学

Outline of Final Research Achievements

The purposes of this study is to evaluate therapeutic effects of human bone marrow mesenchymal stem cells (hMCS) in systemic acute inflammation after crush injury. In this study, administration of hMCS did not show therapeutic effects such as anti-inflammation and tissue repair.