The molecular basis for the treatment of muscle atrophy targeting NF-kB signaling
| Project/Area Number |
16K20424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 骨格筋 / サルコペニア / 骨格筋萎縮 / NF-κB / サテライト細胞 / オーラルフレイル / 筋萎縮 / 細胞分化 / 細胞増殖 / 再生医学 / 歯学 / 老化 |
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| Outline of Final Research Achievements |
The transcription factor nuclear factor κB (NF-κB) signaling has also been shown to be involved in skeletal muscle atrophy. However, the role of NF-κB on the skeletal muscle metabolism and the regenerative capacity of satellite cells during the muscle atrophy process still remains unknown.NF-κB signaling was increased during muscle fiber degradation and during the proliferative stage of satellite cells. In contrast, NF-κB signaling was decreased during the differentiation/fusion stage of satellite cells. Moreover, NF-κB signaling induced muscle fibers degradation and satellite cells proliferation but suppressed differentiation and fusion of satellite cells. These data suggest that inhibitors of NF-κB are potential candidates for the treatment of skeletal muscle atrophy. However, our data also suggests that a stage-specific regulation of NF-κB signaling will be necessary during therapeutic intervention so as not to repress the proliferation of satellite cells.
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Report
(3 results)
Research Products
(10 results)
