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The molecular basis for the treatment of muscle atrophy targeting NF-kB signaling

Research Project

Project/Area Number 16K20424
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionKyushu Dental College

Principal Investigator

Kokabu Shoichiro  九州歯科大学, 歯学部, 准教授 (30448899)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords骨格筋 / サルコペニア / 骨格筋萎縮 / NF-κB / サテライト細胞 / オーラルフレイル / 筋萎縮 / 細胞分化 / 細胞増殖 / 再生医学 / 歯学 / 老化
Outline of Final Research Achievements

The transcription factor nuclear factor κB (NF-κB) signaling has also been shown to be involved in skeletal muscle atrophy. However, the role of NF-κB on the skeletal muscle metabolism and the regenerative capacity of satellite cells during the muscle atrophy process still remains unknown.NF-κB signaling was increased during muscle fiber degradation and during the proliferative stage of satellite cells. In contrast, NF-κB signaling was decreased during the differentiation/fusion stage of satellite cells. Moreover, NF-κB signaling induced muscle fibers degradation and satellite cells proliferation but suppressed differentiation and fusion of satellite cells. These data suggest that inhibitors of NF-κB are potential candidates for the treatment of skeletal muscle atrophy. However, our data also suggests that a stage-specific regulation of NF-κB signaling will be necessary during therapeutic intervention so as not to repress the proliferation of satellite cells.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Harvard University/Marian University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] McGill University(Canada)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Harvard University/Marian University(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] McGill University(CANADA)

    • Related Report
      2016 Research-status Report
  • [Journal Article] On the Emerging Role of the Taste Receptor Type 1 (T1R) Family of Nutrient-Sensors in the Musculoskeletal System2017

    • Author(s)
      S. Kokabu, J.W. Lowery, T. Toyono, T. Sato, T. Yoda,
    • Journal Title

      Molecules

      Volume: 22 Issue: 3 Pages: 1-7

    • DOI

      10.3390/molecules22030469

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells2016

    • Author(s)
      Kokabu S, Lowery JW, Jimi E: Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells.
    • Journal Title

      Stem Cells International

      Volume: - Issue: 1 Pages: 3753581-3753581

    • DOI

      10.1155/2016/3753581

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] NF-κB regulates the differentiation of skeletal muscle stem cells2017

    • Author(s)
      Nakaminami Y, Akaike Y, Shirai K, Kokabu S, Matsubara T, Jimi E
    • Organizer
      Asia-Pacific Conference in FUKUOKA 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TLE3によるMyoD の転写活性制御機構2016

    • Author(s)
      古株彰一郎,中富千尋,松原琢磨,自見英治郎
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] NF-κBシグナル亢進と除神経性骨格筋萎縮2016

    • Author(s)
      古株彰一郎, 中富千尋, 松原琢磨, 自見英治郎
    • Organizer
      第34回日本骨代謝学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] NF-κBシグナルは除神経による骨格筋萎縮初期に亢進する2016

    • Author(s)
      古株彰一郎, 中富千尋, 松原琢磨, 人見涼露, 自見英治郎
    • Organizer
      第76回九州歯科学会総会・学術大会
    • Place of Presentation
      北九州
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-06-09  

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