| Project/Area Number |
16K20436
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAIDA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (40632097)
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| Co-Investigator(Renkei-kenkyūsha) |
MIURA Masahiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10272600)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 固形腫瘍 / 腫瘍内微小環境 / CAM/ECM / 放射線治療 / G2アレスト / 化合物スクリーニング / 放射線 / がん / 細胞周期動態 / 癌 / 細胞周期 / 細胞外因子 / 細胞接着因子 |
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| Outline of Final Research Achievements |
In this study, I revealed the effect of some adhesion factors on radiation-induced G2 arrest kinetics using fluorescent ubiquitination-based cell cycle indicator (Fucci). However, I could not identify the factor determining cell cycle kinetics following the irradiation. In addition, I identified some chemical candidates affecting radiation-induced G2 arrest by using a chemical library composed of 1073 function-known compounds. It is well-known that DNA repair contributes to radiation-induced cell cycle kinetics. Therefore, I will examine whether the candidates can be applied as a radiosensitizer or not, and establish a novel radiosensitization targeting its factor.
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