Development of a new maker for oral epithelial dysplasia by using animal model
| Project/Area Number |
16K20445
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Asahi University |
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Principal Investigator |
Nakao Juna 朝日大学, 歯学部, 助教 (30734173)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 口腔癌 / 上皮性異形成 / 前癌病変 / 白板症 / 免疫組織化学染色 / 上皮異形成症 / 扁平上皮癌 / 上皮異形成 / 次世代シーケンス解析 / 免役組織化学染色 / 歯学 / 癌 / 細胞・組織 |
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| Outline of Final Research Achievements |
Oral epithelial dysplasia is a precursor lesion of oral squamous cell carcinoma. It shows architectural and cellular atypia. However, histopathological diagnosis criteria has a little variation. We investigated a new biomarkers for oral epithelial dysplasia by using rat model and RNA-sequencing. Interestingly, the expression of S100A8 and S100A9 in epithelial dysplasia and squamous cell carcinoma were higher than normal tongue. We focused on S100A8 and S100A9 in oral epithelial cells.
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| Academic Significance and Societal Importance of the Research Achievements |
上皮性異形成は口腔がんの前駆病変であり、早期発見、治療することでがんの発生を抑えることができる。
本研究では病変におけるS100A8, S100A9に発現上昇を明らかにした。上皮性異形成の特徴を形態学的のみならず、分子生物学的に見出すことは、早期発見、診断の新しいマーカー、新規治療薬の開発につながると考えられる。
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Report
(5 results)
Research Products
(2 results)
