| Project/Area Number |
16K20445
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Asahi University |
|---|
Principal Investigator |
Nakao Juna 朝日大学, 歯学部, 助教 (30734173)
|
|---|
| Project Period (FY) |
2016-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 口腔癌 / 上皮性異形成 / 前癌病変 / 白板症 / 免疫組織化学染色 / 上皮異形成症 / 扁平上皮癌 / 上皮異形成 / 次世代シーケンス解析 / 免役組織化学染色 / 歯学 / 癌 / 細胞・組織 |
|---|
| Outline of Final Research Achievements |
Oral epithelial dysplasia is a precursor lesion of oral squamous cell carcinoma. It shows architectural and cellular atypia. However, histopathological diagnosis criteria has a little variation. We investigated a new biomarkers for oral epithelial dysplasia by using rat model and RNA-sequencing. Interestingly, the expression of S100A8 and S100A9 in epithelial dysplasia and squamous cell carcinoma were higher than normal tongue. We focused on S100A8 and S100A9 in oral epithelial cells.
|
| Academic Significance and Societal Importance of the Research Achievements |
上皮性異形成は口腔がんの前駆病変であり、早期発見、治療することでがんの発生を抑えることができる。
本研究では病変におけるS100A8, S100A9に発現上昇を明らかにした。上皮性異形成の特徴を形態学的のみならず、分子生物学的に見出すことは、早期発見、診断の新しいマーカー、新規治療薬の開発につながると考えられる。
|
