Development of novel functional monomer with higher and more stable bonding performance than 10-MDP

• Project/Area Number: 16K20455
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: Yoshihara Kumiko 岡山大学, 大学病院, 助教 (90631581)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 機能性モノマー / 象牙質 / アパタイト / 接着強さ / 歯質接着 / ハイドロキシアパタイト / 界面 / 歯学 / 生体材料

Outline of Final Research Achievements

Functional monomers affect the bond strength and its durability. 10-MDP contains adhesives are known as having good bond durability, however it still shows degradation. More hydrolysis-resistant functional monomers are needed to improve bond durability. In this study, we investigate the chemical interaction between functional monomer and hydroxyapatite and bond strength on dentin in order to develop new functional monomer with enough immediate and long term bond strength. From our study, we found long fluorocarbon monomer revealed higher and more stable bond strength.

Research Products

• [Int'l Joint Research] KULeuven(ベルギー)
• [Int'l Joint Research] Federal University of Ceara at Fortaleza(ブラジル)
• [Int'l Joint Research] KULeuven, BIOMAT(Belgium)
• [Int'l Joint Research] Federal University Ceara(Brazil)
• [Journal Article] Chemical interaction of glycero-phosphate dimethacrylate (GPDM) with hydroxyapatite and dentin. (2018)
  • Author(s): Yoshihara K, Nagaoka N, Hayakawa S, Okihara T, Yoshida Y, Van Meerbeek B.
  • Journal Title: Dental Materials Volume: 34
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Etching Efficacy of Self-Etching Functional Monomers (2018)
  • Author(s): Yoshihara K.、Hayakawa S.、Nagaoka N.、Okihara T.、Yoshida Y.、Van Meerbeek B.
  • Journal Title: Journal of Dental Research Volume: 印刷中 Issue: 9 Pages: 1-7
  • DOI: 10.1177/0022034518763606
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Freshly-mixed and setting calcium-silicate cements stimulate human dental pulp cells (2018)
  • Author(s): Pedano M, Li X, Li S, Sun Z, Cokic S, Putzeys E, Yoshihara K, Yoshida Y, Chen Z, Van Landuyt K, Van Meerbeek B
  • Journal Title: Dental Materials Volume: 印刷中 Issue: 5 Pages: 1-12
  • DOI: 10.1016/j.dental.2018.02.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Crystallographic and morphological analysis of sandblasted highly translucent dental zirconia (2018)
  • Author(s): Inokoshi Masanao、Shimizu Haruki、Nozaki Kosuke、Takagaki Tomohiro、Yoshihara Kumiko、Nagaoka Noriyuki、Zhang Fei、Vleugels Jozef、Van Meerbeek Bart、Minakuchi Shunsuke
  • Journal Title: Dental Materials Volume: 34 Issue: 3 Pages: 508-518
  • DOI: 10.1016/j.dental.2017.12.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Light irradiance through novel CAD-CAM block materials and degree of conversion of composite cement (2018)
  • Author(s): Lise Diogo Pedrollo、Van Ende Annelies、De Munck Jan、Yoshihara Kumiko、Nagaoka Noriyuki、Cardoso Vieira Luiz Clovis、Van Meerbeek Bart
  • Journal Title: Dental Materials Volume: 34 Issue: 2 Pages: 296-305
  • DOI: 10.1016/j.dental.2017.11.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Micro-Raman Vibrational Identification of 10-MDP Bond to Zirconia and Shear Bond Strength Analysis (2017)
  • Author(s): De-Paula Diego Martins、Loguercio Alessandro D.、Reis Alessandra、Frota Natasha Marques、Melo Radames、Yoshihara Kumiko、Feitosa Victor Pinheiro
  • Journal Title: BioMed Research International. Volume: 2017 Pages: 1-7
  • DOI: 10.1155/2017/8756396
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Titanium implant functionalization with phosphate-containing polymers may favour in vivo osseointegration (2017)
  • Author(s): Cardoso MV, de Rycker J, Chaudhari A, Coutinho E, Yoshida Y, Van Meerbeek B, Mesquita MF, da Silva WJ, Yoshihara K, Vandamme K, Duyck J
  • Journal Title: J Clin Periodontology Volume: 44 Issue: 9 Pages: 950-960
  • DOI: 10.1111/jcpe.12736
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bacterial adhesion not inhibited by ion-releasing bioactive glass filler (2017)
  • Author(s): Yoshihara Kumiko、Nagaoka Noriyuki、Maruo Yukinori、Sano Hidehiko、Yoshida Yasuhiro、Van Meerbeek Bart
  • Journal Title: Dental Materials Volume: 33 Issue: 6 Pages: 723-734
  • DOI: 10.1016/j.dental.2017.04.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical interaction mechanism of 10-MDP with zirconia (2017)
  • Author(s): Noriyuki Nagaoka, Kumiko Yoshihara, Victor Pinheiro Feitosa, Yoshiyuki Tamada, Masao Irie, Yasuhiro Yoshida, Bart Van Meerbeek, Satoshi Hayakawa
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 45563-45563
  • DOI: 10.1038/srep45563
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model. (2017)
  • Author(s): Cardoso MV, Chaudhari A, Yoshihara K, Mesquita MF, Yoshida Y, Van Meerbeek B, Vandamme K, Duyck J.
  • Journal Title: Int J Oral Maxillofac Implants. Volume: 32 Issue: 2 Pages: 282-290
  • DOI: 10.11607/jomi.5074
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Re-mineralizing dentin using an experimental tricalcium silicate cement with biomimetic analogs. (2017)
  • Author(s): Li X, De Munck J, Yoshihara K, Pedano M, Van Landuyt K, Chen Z, Van Meerbeek B.
  • Journal Title: Dental Materials Volume: 33 Issue: 5 Pages: 505-513
  • DOI: 10.1016/j.dental.2017.02.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sandblasting may damage the surface composite CAD-CAM blocks. (2017)
  • Author(s): Yoshihara K, Nagaoka N, Maruo Y, Nishigawa G, Irie M, Yoshida Y, Ban Meerbeek B.
  • Journal Title: Dental Materials Volume: 33 Issue: 3 Pages: 124-135
  • DOI: 10.1016/j.dental.2016.12.003
  • NAID: 120006401576
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Does 8-methacryloxyoctyl trimethoxy silane (8-MOTS) improve initial bond strength on lithium disilicate glass ceramic? (2017)
  • Author(s): Maruo Y, Nishigawa G, Yoshihara K, Minagi S, Matsumoto T, Irie M.
  • Journal Title: Dental Materials Volume: 33 Issue: 3 Pages: 95-100
  • DOI: 10.1016/j.dental.2016.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Modified tricalcium silicate cement formulations with added zirconium oxide. (2017)
  • Author(s): Li X, Yoshihara K, De Munck J, Cokic S, Pongprueksa P, Putzeys E, Pedano M, Chen Z, Van Landuyt K, Van Meerbeek B.
  • Journal Title: Clinical Oral Investigations Volume: 21 Issue: 3 Pages: 895-895
  • DOI: 10.1007/s00784-016-1843-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Does acid etching morphologically and chemically affect lithium disilicate glass ceramic surfaces? (2017)
  • Author(s): Maruo Y, Nishigawa G, Irie M, Yoshihara K, Matsumoto T, Minagi S.
  • Journal Title: Journal of Applied Biomaterials & Functional Materials Volume: 15 Issue: 1 Pages: 1218-1225
  • DOI: 10.5301/jabfm.5000303
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] No evidence for the growth-stimulating effect of monomers on cariogenic Streptococci. (2016)
  • Author(s): Nedeljkovic I, Yoshihara K, De Munck J, Teughels W, Van Meerbeek B, Van Landuyt KL.
  • Journal Title: Clinical Oral Investigations Volume: in Press Issue: 5 Pages: 1861-1869
  • DOI: 10.1007/s00784-016-1972-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effectiveness and stability of silane coupling agent incorporated in ‘universal’ adhesives (2016)
  • Author(s): Kumiko Yoshihara, Noriyuki Nagaoka, Akinari Sonoda, Yukinori Maruo, Yoji Makita, Takumi Okihara, Masao Irie, Yasuhiro Yoshida, Bart Van Meerbeek
  • Journal Title: Dental Materials Volume: 32 Issue: 10 Pages: 1218-1225
  • DOI: 10.1016/j.dental.2016.07.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interference of functional monomers with polymerization efficiency of adhesives (2016)
  • Author(s): Hanabusa M, Yoshihara K, Yoshida Y, Okihara T, Yamamoto T, Momoi Y, Van Meerbeek B
  • Journal Title: European Journal of Oral Sciences Volume: 124 Issue: 2 Pages: 204-209
  • DOI: 10.1111/eos.12245
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] EDS-(S)TEM observation and analysis of dentin caries re-mineralization (2017)
  • Author(s): Yoshihara K, Nagaoka N, Hara T, Nakamura A, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/AADR/CADR General Session & Exhibition
  • Place of Presentation: San Francisco, Calif., USA
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] Chemical interaction of a novel functional monomer with hydroxyapatite/dentin (2017)
  • Author(s): Yoshihara K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/AADR/CADR General Session & Exhibition
  • Place of Presentation: San Francisco, Calif., USA
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] The effect of phosphoric-acid cleaning on chemical interaction of 10-MDP with zirconia. (2017)
  • Author(s): Yoshihara K, Nagaoka N, Yoshida Y, Van Meerbeek B, Hayakawa S..
  • Organizer: The annual meeting of Asia Bioceramic Society
  • Int'l Joint Research
• [Presentation] レジンセメントの曲げ強さに対する長期水中保管の影響 (2017)
  • Author(s): 吉原久美子, 長岡紀幸, 入江正郎，吉田靖弘
  • Organizer: 第36回日本接着歯学会学術大会
• [Presentation] Chemical Interaction Between 10-MDP in Glass Ionomer Cement And Teeth/zirconia (2017)
  • Author(s): Yoshihara K
  • Organizer: Brazil-Japan Joint research workshop on adhesive dentistry
  • Int'l Joint Research
• [Presentation] アルカリ環境が修復材料の耐久性に与える影響 (2017)
  • Author(s): 吉原 久美子, 長岡 紀幸, 小河 達之,吉田 靖弘
  • Organizer: 147回日本歯科保存学会春季学術大会
• [Presentation] Development of Self adhesive pulp capping agents containing a novel acrylamide monomer (2017)
  • Author(s): Yoshihara K, Nagaoka N, Yoshida Y, Van Meerbeek B.
  • Organizer: CED-IADR
  • Int'l Joint Research
• [Presentation] Rechargeable anti-bacterial efficacy of montmorillonite modified with cetylpyridinium chloride for dental materials (2017)
  • Author(s): Yoshihara K, Abe S, Nagaoka N, Makita Y, Obika H, Van Meerveek B, Yoshida Y.
  • Organizer: ADVANCES IN FUNCTIONAL MATERIALS
  • Int'l Joint Research
• [Presentation] 異なる種類のフィラーが1液型ボンディング材の粘性、耐久性に与える影響 (2017)
  • Author(s): 吉原久美子, 小河達之, 長岡紀幸, 吉田靖弘
  • Organizer: 146回日本歯科保存学会春季学術大会
• [Presentation] 10-MDP プライマー処理前の洗浄がジルコニアの接着に及ぼす影響 (2017)
  • Author(s): 吉原 久美子, 長岡 紀幸,丸尾 幸憲, 吉田 靖弘
  • Organizer: 日本補綴歯科学会第126回学術大会
• [Presentation] アクリルアミド系モノマー含有レジン添加型覆髄材の検討 (2017)
  • Author(s): 吉原 久美子, 長岡 紀幸,吉田 靖弘
  • Organizer: 第69回 歯科理工学会 春期学術講演会
• [Presentation] 2ステップセルフエッチングボンディング材の長期臨床症例の接着界面観察 (2016)
  • Author(s): 吉原久美子，長岡紀幸，吉田靖弘
  • Organizer: 第35回接着歯学会学術大会
  • Place of Presentation: 北海道大学 学術交流会館
  • Year and Date: 2016-12-03
• [Presentation] リン酸エッチングの有無がユニバーサルアドヒーシブの象牙質接着耐久性に与える影響 (2016)
  • Author(s): 吉原久美子，長岡紀幸，吉田靖弘
  • Organizer: 第145回日本歯科保存学会 平成28年度秋季大会
  • Place of Presentation: キッセイ文化ホール （長野県松本文化会館）
  • Year and Date: 2016-10-27
• [Presentation] バイオアクティブガラス含有歯質接着剤の電子顕微鏡観察 (2016)
  • Author(s): 長岡紀幸，吉原久美子，吉田靖弘
  • Organizer: 第145回日本歯科保存学会 平成28年度秋季大会
  • Place of Presentation: キッセイ文化ホール （長野県松本文化会館）
  • Year and Date: 2016-10-27
• [Presentation] インプラント/骨界面の３次元観察 (2016)
  • Author(s): 長岡紀幸，吉原久美子，丸尾幸憲
  • Organizer: 第58回歯科基礎医学会学術大会サテライトシンポジウム
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2016-08-24
• [Presentation] リチウムシリケートセラミックの構造観察と分析 (2016)
  • Author(s): 吉原久美子，長岡紀幸，丸尾幸憲，西川悟郎，吉田靖弘
  • Organizer: 日本補綴歯科学会第125回学術大会
  • Place of Presentation: 石川県立音楽堂，ANAクラウンプラザホテル金沢
  • Year and Date: 2016-07-08
• [Presentation] Etching efficacy of self-etching functional monomers (2016)
  • Author(s): Yoshihara K, Watanabe S, Nagaoka N, Okihara T, Hayakawa S, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/APR General Session & Exhibition
  • Place of Presentation: Seoul, Republic of Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] Competitive interaction of 10-MDP and 4-MET with hydroxyapatite (2016)
  • Author(s): Yoshihara K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/APR General Session & Exhibition
  • Place of Presentation: Seoul, Republic of Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] Bioactive glass フィラー含有コンポジットレジンの表面性状の検討 (2016)
  • Author(s): 吉原久美子，長岡紀幸，佐野英彦，吉田靖弘
  • Organizer: 第144回日本歯科保存学会 平成28年度春季大会
  • Place of Presentation: 栃木県総合文化センター
  • Year and Date: 2016-06-09
• [Presentation] アクリルアミド系モノマー含有レジン系接着性シーラーの検討 (2016)
  • Author(s): 吉原久美子，長岡紀幸，吉田靖弘
  • Organizer: 第76回歯科理工学会春季学術講演会
  • Place of Presentation: 九州大学医学部百年講堂
  • Year and Date: 2016-04-16