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Development of novel functional monomer with higher and more stable bonding performance than 10-MDP

Research Project

Project/Area Number 16K20455
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionOkayama University

Principal Investigator

Yoshihara Kumiko  岡山大学, 大学病院, 助教 (90631581)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords機能性モノマー / 象牙質 / アパタイト / 接着強さ / 歯質接着 / ハイドロキシアパタイト / 界面 / 歯学 / 生体材料
Outline of Final Research Achievements

Functional monomers affect the bond strength and its durability. 10-MDP contains adhesives are known as having good bond durability, however it still shows degradation. More hydrolysis-resistant functional monomers are needed to improve bond durability. In this study, we investigate the chemical interaction between functional monomer and hydroxyapatite and bond strength on dentin in order to develop new functional monomer with enough immediate and long term bond strength. From our study, we found long fluorocarbon monomer revealed higher and more stable bond strength.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (42 results)

All 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (18 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 18 results,  Open Access: 10 results,  Acknowledgement Compliant: 2 results) Presentation (20 results) (of which Int'l Joint Research: 8 results)

  • [Int'l Joint Research] KULeuven(ベルギー)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Federal University of Ceara at Fortaleza(ブラジル)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] KULeuven, BIOMAT(Belgium)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Federal University Ceara(Brazil)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Chemical interaction of glycero-phosphate dimethacrylate (GPDM) with hydroxyapatite and dentin.2018

    • Author(s)
      Yoshihara K, Nagaoka N, Hayakawa S, Okihara T, Yoshida Y, Van Meerbeek B.
    • Journal Title

      Dental Materials

      Volume: 34

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Etching Efficacy of Self-Etching Functional Monomers2018

    • Author(s)
      Yoshihara K.、Hayakawa S.、Nagaoka N.、Okihara T.、Yoshida Y.、Van Meerbeek B.
    • Journal Title

      Journal of Dental Research

      Volume: 印刷中 Issue: 9 Pages: 1-7

    • DOI

      10.1177/0022034518763606

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Freshly-mixed and setting calcium-silicate cements stimulate human dental pulp cells2018

    • Author(s)
      Pedano M, Li X, Li S, Sun Z, Cokic S, Putzeys E, Yoshihara K, Yoshida Y, Chen Z, Van Landuyt K, Van Meerbeek B
    • Journal Title

      Dental Materials

      Volume: 印刷中 Issue: 5 Pages: 1-12

    • DOI

      10.1016/j.dental.2018.02.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crystallographic and morphological analysis of sandblasted highly translucent dental zirconia2018

    • Author(s)
      Inokoshi Masanao、Shimizu Haruki、Nozaki Kosuke、Takagaki Tomohiro、Yoshihara Kumiko、Nagaoka Noriyuki、Zhang Fei、Vleugels Jozef、Van Meerbeek Bart、Minakuchi Shunsuke
    • Journal Title

      Dental Materials

      Volume: 34 Issue: 3 Pages: 508-518

    • DOI

      10.1016/j.dental.2017.12.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Light irradiance through novel CAD-CAM block materials and degree of conversion of composite cement2018

    • Author(s)
      Lise Diogo Pedrollo、Van Ende Annelies、De Munck Jan、Yoshihara Kumiko、Nagaoka Noriyuki、Cardoso Vieira Luiz Clovis、Van Meerbeek Bart
    • Journal Title

      Dental Materials

      Volume: 34 Issue: 2 Pages: 296-305

    • DOI

      10.1016/j.dental.2017.11.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Micro-Raman Vibrational Identification of 10-MDP Bond to Zirconia and Shear Bond Strength Analysis2017

    • Author(s)
      De-Paula Diego Martins、Loguercio Alessandro D.、Reis Alessandra、Frota Natasha Marques、Melo Radames、Yoshihara Kumiko、Feitosa Victor Pinheiro
    • Journal Title

      BioMed Research International.

      Volume: 2017 Pages: 1-7

    • DOI

      10.1155/2017/8756396

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Titanium implant functionalization with phosphate-containing polymers may favour in vivo osseointegration2017

    • Author(s)
      Cardoso MV, de Rycker J, Chaudhari A, Coutinho E, Yoshida Y, Van Meerbeek B, Mesquita MF, da Silva WJ, Yoshihara K, Vandamme K, Duyck J
    • Journal Title

      J Clin Periodontology

      Volume: 44 Issue: 9 Pages: 950-960

    • DOI

      10.1111/jcpe.12736

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bacterial adhesion not inhibited by ion-releasing bioactive glass filler2017

    • Author(s)
      Yoshihara Kumiko、Nagaoka Noriyuki、Maruo Yukinori、Sano Hidehiko、Yoshida Yasuhiro、Van Meerbeek Bart
    • Journal Title

      Dental Materials

      Volume: 33 Issue: 6 Pages: 723-734

    • DOI

      10.1016/j.dental.2017.04.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical interaction mechanism of 10-MDP with zirconia2017

    • Author(s)
      Noriyuki Nagaoka, Kumiko Yoshihara, Victor Pinheiro Feitosa, Yoshiyuki Tamada, Masao Irie, Yasuhiro Yoshida, Bart Van Meerbeek, Satoshi Hayakawa
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 45563-45563

    • DOI

      10.1038/srep45563

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model.2017

    • Author(s)
      Cardoso MV, Chaudhari A, Yoshihara K, Mesquita MF, Yoshida Y, Van Meerbeek B, Vandamme K, Duyck J.
    • Journal Title

      Int J Oral Maxillofac Implants.

      Volume: 32 Issue: 2 Pages: 282-290

    • DOI

      10.11607/jomi.5074

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Re-mineralizing dentin using an experimental tricalcium silicate cement with biomimetic analogs.2017

    • Author(s)
      Li X, De Munck J, Yoshihara K, Pedano M, Van Landuyt K, Chen Z, Van Meerbeek B.
    • Journal Title

      Dental Materials

      Volume: 33 Issue: 5 Pages: 505-513

    • DOI

      10.1016/j.dental.2017.02.003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sandblasting may damage the surface composite CAD-CAM blocks.2017

    • Author(s)
      Yoshihara K, Nagaoka N, Maruo Y, Nishigawa G, Irie M, Yoshida Y, Ban Meerbeek B.
    • Journal Title

      Dental Materials

      Volume: 33 Issue: 3 Pages: 124-135

    • DOI

      10.1016/j.dental.2016.12.003

    • NAID

      120006401576

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Does 8-methacryloxyoctyl trimethoxy silane (8-MOTS) improve initial bond strength on lithium disilicate glass ceramic?2017

    • Author(s)
      Maruo Y, Nishigawa G, Yoshihara K, Minagi S, Matsumoto T, Irie M.
    • Journal Title

      Dental Materials

      Volume: 33 Issue: 3 Pages: 95-100

    • DOI

      10.1016/j.dental.2016.11.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified tricalcium silicate cement formulations with added zirconium oxide.2017

    • Author(s)
      Li X, Yoshihara K, De Munck J, Cokic S, Pongprueksa P, Putzeys E, Pedano M, Chen Z, Van Landuyt K, Van Meerbeek B.
    • Journal Title

      Clinical Oral Investigations

      Volume: 21 Issue: 3 Pages: 895-895

    • DOI

      10.1007/s00784-016-1843-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Does acid etching morphologically and chemically affect lithium disilicate glass ceramic surfaces?2017

    • Author(s)
      Maruo Y, Nishigawa G, Irie M, Yoshihara K, Matsumoto T, Minagi S.
    • Journal Title

      Journal of Applied Biomaterials & Functional Materials

      Volume: 15 Issue: 1 Pages: 1218-1225

    • DOI

      10.5301/jabfm.5000303

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] No evidence for the growth-stimulating effect of monomers on cariogenic Streptococci.2016

    • Author(s)
      Nedeljkovic I, Yoshihara K, De Munck J, Teughels W, Van Meerbeek B, Van Landuyt KL.
    • Journal Title

      Clinical Oral Investigations

      Volume: in Press Issue: 5 Pages: 1861-1869

    • DOI

      10.1007/s00784-016-1972-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effectiveness and stability of silane coupling agent incorporated in ‘universal’ adhesives2016

    • Author(s)
      Kumiko Yoshihara, Noriyuki Nagaoka, Akinari Sonoda, Yukinori Maruo, Yoji Makita, Takumi Okihara, Masao Irie, Yasuhiro Yoshida, Bart Van Meerbeek
    • Journal Title

      Dental Materials

      Volume: 32 Issue: 10 Pages: 1218-1225

    • DOI

      10.1016/j.dental.2016.07.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interference of functional monomers with polymerization efficiency of adhesives2016

    • Author(s)
      Hanabusa M, Yoshihara K, Yoshida Y, Okihara T, Yamamoto T, Momoi Y, Van Meerbeek B
    • Journal Title

      European Journal of Oral Sciences

      Volume: 124 Issue: 2 Pages: 204-209

    • DOI

      10.1111/eos.12245

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] EDS-(S)TEM observation and analysis of dentin caries re-mineralization2017

    • Author(s)
      Yoshihara K, Nagaoka N, Hara T, Nakamura A, Yoshida Y, Van Meerbeek B
    • Organizer
      IADR/AADR/CADR General Session & Exhibition
    • Place of Presentation
      San Francisco, Calif., USA
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chemical interaction of a novel functional monomer with hydroxyapatite/dentin2017

    • Author(s)
      Yoshihara K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B
    • Organizer
      IADR/AADR/CADR General Session & Exhibition
    • Place of Presentation
      San Francisco, Calif., USA
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of phosphoric-acid cleaning on chemical interaction of 10-MDP with zirconia.2017

    • Author(s)
      Yoshihara K, Nagaoka N, Yoshida Y, Van Meerbeek B, Hayakawa S..
    • Organizer
      The annual meeting of Asia Bioceramic Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レジンセメントの曲げ強さに対する長期水中保管の影響2017

    • Author(s)
      吉原久美子, 長岡紀幸, 入江正郎,吉田靖弘
    • Organizer
      第36回日本接着歯学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chemical Interaction Between 10-MDP in Glass Ionomer Cement And Teeth/zirconia2017

    • Author(s)
      Yoshihara K
    • Organizer
      Brazil-Japan Joint research workshop on adhesive dentistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルカリ環境が修復材料の耐久性に与える影響2017

    • Author(s)
      吉原 久美子, 長岡 紀幸, 小河 達之,吉田 靖弘
    • Organizer
      147回日本歯科保存学会春季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of Self adhesive pulp capping agents containing a novel acrylamide monomer2017

    • Author(s)
      Yoshihara K, Nagaoka N, Yoshida Y, Van Meerbeek B.
    • Organizer
      CED-IADR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rechargeable anti-bacterial efficacy of montmorillonite modified with cetylpyridinium chloride for dental materials2017

    • Author(s)
      Yoshihara K, Abe S, Nagaoka N, Makita Y, Obika H, Van Meerveek B, Yoshida Y.
    • Organizer
      ADVANCES IN FUNCTIONAL MATERIALS
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 異なる種類のフィラーが1液型ボンディング材の粘性、耐久性に与える影響2017

    • Author(s)
      吉原久美子, 小河達之, 長岡紀幸, 吉田靖弘
    • Organizer
      146回日本歯科保存学会春季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 10-MDP プライマー処理前の洗浄がジルコニアの接着に及ぼす影響2017

    • Author(s)
      吉原 久美子, 長岡 紀幸,丸尾 幸憲, 吉田 靖弘
    • Organizer
      日本補綴歯科学会第126回学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アクリルアミド系モノマー含有レジン添加型覆髄材の検討2017

    • Author(s)
      吉原 久美子, 長岡 紀幸,吉田 靖弘
    • Organizer
      第69回 歯科理工学会 春期学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2ステップセルフエッチングボンディング材の長期臨床症例の接着界面観察2016

    • Author(s)
      吉原久美子,長岡紀幸,吉田靖弘
    • Organizer
      第35回接着歯学会学術大会
    • Place of Presentation
      北海道大学 学術交流会館
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
  • [Presentation] リン酸エッチングの有無がユニバーサルアドヒーシブの象牙質接着耐久性に与える影響2016

    • Author(s)
      吉原久美子,長岡紀幸,吉田靖弘
    • Organizer
      第145回日本歯科保存学会 平成28年度秋季大会
    • Place of Presentation
      キッセイ文化ホール (長野県松本文化会館)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] バイオアクティブガラス含有歯質接着剤の電子顕微鏡観察2016

    • Author(s)
      長岡紀幸,吉原久美子,吉田靖弘
    • Organizer
      第145回日本歯科保存学会 平成28年度秋季大会
    • Place of Presentation
      キッセイ文化ホール (長野県松本文化会館)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] インプラント/骨界面の3次元観察2016

    • Author(s)
      長岡紀幸,吉原久美子,丸尾幸憲
    • Organizer
      第58回歯科基礎医学会学術大会サテライトシンポジウム
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] リチウムシリケートセラミックの構造観察と分析2016

    • Author(s)
      吉原久美子,長岡紀幸,丸尾幸憲,西川悟郎,吉田靖弘
    • Organizer
      日本補綴歯科学会第125回学術大会
    • Place of Presentation
      石川県立音楽堂,ANAクラウンプラザホテル金沢
    • Year and Date
      2016-07-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Etching efficacy of self-etching functional monomers2016

    • Author(s)
      Yoshihara K, Watanabe S, Nagaoka N, Okihara T, Hayakawa S, Yoshida Y, Van Meerbeek B
    • Organizer
      IADR/APR General Session & Exhibition
    • Place of Presentation
      Seoul, Republic of Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Competitive interaction of 10-MDP and 4-MET with hydroxyapatite2016

    • Author(s)
      Yoshihara K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B
    • Organizer
      IADR/APR General Session & Exhibition
    • Place of Presentation
      Seoul, Republic of Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bioactive glass フィラー含有コンポジットレジンの表面性状の検討2016

    • Author(s)
      吉原久美子,長岡紀幸,佐野英彦,吉田靖弘
    • Organizer
      第144回日本歯科保存学会 平成28年度春季大会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] アクリルアミド系モノマー含有レジン系接着性シーラーの検討2016

    • Author(s)
      吉原久美子,長岡紀幸,吉田靖弘
    • Organizer
      第76回歯科理工学会春季学術講演会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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