The functional analysis of WISP1 gene in the development and aggravation of osteoarthritis

• Project/Area Number: 16K20499
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Okayama University
• Principal Investigator: Maeda Azusa 岡山大学, 岡山大学病院, 医員 (70754662)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 変形性関節症 / 軟骨細胞 / 歯学 / WISP1/CCN4 / 軟骨

Outline of Final Research Achievements

The purpose of this study was to elucidate the relationship between WISP1 gene and osteoarthritis (OA). In this study, we focused on BMP2 which is regulated by WISP1 and showed that negative feedback mechanism in BMP signaling works during the process of chondrogenic differentiation and chondrogenic differentiation was controlled by BMP antagonist. This result suggests that WISP1 regulates chondrogenic differentiation through the negative feedback mechanism in BMP signaling while in an indirect way.