• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Fabrication of Carbonate Apatite-type Bone Cement which enables both Bone Reconstruction and Hemostasis

Research Project

Project/Area Number 16K20505
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNational Institute of Advanced Industrial Science and Technology (2018)
Kyushu University (2016-2017)

Principal Investigator

Sugiura Yuki  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (70755040)

Research Collaborator Ishikawa Kunio  
Tsuru Kanji  
Tsuchiya Akira  
Melvin Munar L.  
Makita Yoji  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords炭酸アパタイト / 骨補填材 / セメント / 連通多孔体 / 生体親和性 / リン酸カルシウム / 人工骨 / 骨セメント / 整形外科 / 成型体 / 生体材料 / タイムコントロール
Outline of Final Research Achievements

Although carbonate apatite (CO3Ap) granule, an analogue of inorganic component of biological bone, is an attractive material as bone substitute, the serious drawback of its is describing as flowing out by bleeding from implanted bone defect during operation. For suitable operating of CO3Ap granules as a bone substitute, it is essentially necessary to attach controlling bleeding and self-setting ability for CO3Ap granules. In this study, we investigated how control the bleeding, an essential matter of granules flowing out from implanted bone defects. In addition, we also tried to attach interconnected porous structure formation ability after implantation. Mixing with biocompatible polymers enabled CO3Ap to attach such bleeding controlling ability and increase its operability. Further in vivo studies will indicate the utility of this mechanism.

Academic Significance and Societal Importance of the Research Achievements

病気や怪我で欠損した骨欠損部に埋入し、機能を回復させる材料の開発は、超高齢化社会を迎えるにあたり、その必要性が増々増大している。生体骨と同じ成分であるCO3Apが主成分の骨補填材は、広く臨床応用されている水酸アパタイトと異なり、骨芽細胞の分化を促進、破骨細胞に吸収される、圧倒的に優れる骨伝導性を示すこと、そして生体骨に置換されることが報告されている。しかし、出血などにより術野より流出してしまうことが課題である。このため、硬化性、止血性を付与することで、CO3Apの本来の機能を発揮させる試みは非常に重要である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2019 2018 2017 2016

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Fabrication of pure octacalcium phosphate blocks from dicalcium hydrogen phosphate dihydrate blocks via a dissolution-precipitation reaction in a basic solution2019

    • Author(s)
      Yuki Sugiura, Kunio Ishikawa
    • Journal Title

      Materials Letters

      Volume: 239 Pages: 143-146

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Sodium inhibits the formation of ammonium-substituted solid solutions of octacalcium phosphate formation by filling its substitution site2019

    • Author(s)
      Yuki Sugiura, Yoji Makita
    • Journal Title

      Dalton Trans

      Volume: 48 Pages: 1386-1386

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effect of Calcium and Phosphate on Compositional Conversion from Dicalcium Hydrogen Phosphate Dihydrate Blocks to Octacalcium Phosphate Blocks2018

    • Author(s)
      Yuki Sugiura, Kunio Ishikawa
    • Journal Title

      Crystals

      Volume: 8 Pages: 222-229

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ammonium Substitutional Solid Solution of Octacalcium Phosphate (OCP)2018

    • Author(s)
      Yuki Sugiura, Yoji Makita
    • Journal Title

      Chem. Lett.

      Volume: 47 Pages: 1371-1374

    • NAID

      130007504956

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor2018

    • Author(s)
      Yuki Sugiura, Melvin L. Munar, Kunio Ishikawa
    • Journal Title

      J. Mater. Sci. Mater. Med.

      Volume: 29 Pages: 151-158

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility evaluation of low-crystallinity b-tricalcium phosphate blocks as a bone substitute fabricated by a dissolution–precipitation reaction from α-tricalcium phosphate blocks.2018

    • Author(s)
      Garima Tripathi, Yuki Sugiura, Aivaras Kareiva, Edita Garskaite, Kanji Tsuru, Kunio Ishikawa
    • Journal Title

      J. Biomater. Appl.

      Volume: 33 Pages: 259-270

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In Vivo stability evaluation of Mg substituted low crystallinity b-tricalcium phosphate blocks fabricated through dissolution–precipitation reaction for fast bone regeneration2018

    • Author(s)
      Garima Tripathi, Yuki Sugiura, Kanji Tsuru, Kunio Ishikawa
    • Journal Title

      Biomed. Mater.

      Volume: 13

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of carbonate apatite blocks from octacalcium phosphate blocks through different phase conversion mode depending on carbonate concentration2018

    • Author(s)
      Yuki Sugiura, Kunio Ishikawa
    • Journal Title

      J. Solid State Chem.

      Volume: 267 Pages: 85-91

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Fabrication of calcite-coated rough-surface titanium using calcium nitrate2018

    • Author(s)
      Rui Shi, Yuki Sugiura, Kanji Tsuru, Kunio Ishikawa
    • Journal Title

      Surf. Coat. Tech.

      Volume: 356 Pages: 72-79

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Sodium Induces Octacalcium Phosphate Formation and Enhances its Layer Structure by Affecting to Hydrous Layer Phosphate2018

    • Author(s)
      Yuki Sugiura, Yoji Makita
    • Journal Title

      Cryst. Growth Des.

      Volume: 18 Pages: 6165-6171

    • Related Report
      2018 Annual Research Report
  • [Journal Article] “Fabrication of arbitrarily shaped carbonate apatite foam based on the interlocking process of dicalcium hydrogen phosphate dihydrate”2017

    • Author(s)
      Sugiura Yuki、Tsuru Kanji、Ishikawa Kunio
    • Journal Title

      Journal of Materials Science: Materials in Medicine

      Volume: 28 Issue: 8 Pages: 122-128

    • DOI

      10.1007/s10856-017-5937-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Carbonate Apatite Block through a Dissolution-Precipitation Reaction Using Calcium Hydrogen Phosphate Dihydrate Block as a Precursor2017

    • Author(s)
      Kanji Tsuru, Ayami Yoshimoto, Masayuki Kanazawa, Yuki Sugiura, Yasuharu Nakashima and Kunio Ishikawa
    • Journal Title

      Materials

      Volume: 10 Issue: 4 Pages: 374-374

    • DOI

      10.3390/ma10040374

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of carbonate apatite pseudomorph from highly soluble acidic calcium phosphate salts through carbonation2016

    • Author(s)
      Sugiura Y., Tsuru K., Ishikawa K
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 124 Issue: 8 Pages: 827-832

    • DOI

      10.2109/jcersj2.16046

    • NAID

      130005255811

    • ISSN
      1348-6535, 1882-0743
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enhancement of HPO<sub>4</sub>&ndash;OH layered structure in octacalcium phosphate and its morphological evolution by acetic acid2016

    • Author(s)
      Sugiura Y., Onuma K., Yamazaki A.
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 124 Issue: 11 Pages: 1178-1184

    • DOI

      10.2109/jcersj2.16169

    • NAID

      130005277234

    • ISSN
      1348-6535, 1882-0743
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Fabrication of carbonate apatite foam from the set calcium sulfate hemihydrate foam via solution mediated phase conversion2016

    • Author(s)
      Sugiura Y., Tsuru K., Ishikawa K
    • Organizer
      International Dental Material Conference
    • Place of Presentation
      インドネシア、バリ島
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Direct fabrication of carbonate apatite foam from calcium sulfate hemihydrate foam via solution mediated phase conversion2016

    • Author(s)
      Sugiura Y., Tsuru K., Ishikawa K.
    • Organizer
      Bioceramics28
    • Place of Presentation
      アメリカ、シャーロット
    • Year and Date
      2016-10-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 酢酸によるOCP中のHPO4-OHレイヤー構造の発達と、OCP結晶性の上昇2016

    • Author(s)
      杉浦 悠紀、小沼 一雄、山崎 淳司、石川 邦夫
    • Organizer
      第20回生体関連セラミックス討論会
    • Place of Presentation
      大阪大学・吹田キャンパス
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi