| Project/Area Number |
16K20612
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Saitama Medical University |
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Principal Investigator |
|
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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|---|
| Keywords | MICA / RANKL / 歯肉癌 / 歯肉癌上皮細胞 / MICA遺伝子 / NKG2Dリガンド / NKG2D / MICA/MICB / NK細胞/T細胞 |
|---|
| Outline of Final Research Achievements |
Physiologically, in bone remodeling, the source of RANKL is osteoblast and osteocyte. However, we hypothesized that RANKL expression derived from gingival epithelial carcinoma cells may be increased in gingival cancer. As a result, overexpression of MICA in gingival epithelial carcinoma cells induced RANKL expression and the supernatant of these cells promoted osteoclastogenesis.
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