| Project/Area Number |
16K20626
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
Sadaoka Sunao 松本歯科大学, 歯学部, 助教 (80549395)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬剤関連顎骨壊死 / クロモグラニンＡ / ビスフォスフォネート / デノスマブ / ChgA / iNOS / NF-κB / 顎骨壊死 / NBP / 窒素含有ビスフォスフォネート製剤 / 抗RANKLモノクローナル抗体製剤 / 抗RANKL製剤 / BRONJ / クロモグラニンA / 骨芽細胞 / 歯骨細胞 / 口腔外科 |
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| Outline of Final Research Achievements |
The developmental mechanism of ARONJ/BRONJ (Anti-resorptive agents-related osteonecrosis of the jaw/Bisphophonate-related osteonecrosis of the jaw) is still unknown.It is suspected that osteoclasts do not resorb old bone, and oral bacterial infection will be coerced.NF-kB is thought to play an important role in promotion of the differentiation of osteoclasts and the resorption of bone.We thought that the onset inhibition by MRONJ had to balance absorption of necrotic bone formation by NF-kB.It is said that ChgA regulates NF-κB. ChgA acts on scavenger receptor (SR-A) and causes iNOS production through NF-kB.We search the oxidative stress cascade which causes MRONJ by LPS and medicine becoming unbalance of the bone remodeling through ChgA.When we used LPS and Denosmub compositely, 3T3-E1 and the ChgA expression on RAW264.7 cells increased.Expression was increased in particular on the 3T3-E1 cells
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