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Imbalanced host development and homeostasis of Drosophila larva by endoparasitic wasp infection

Research Project

Project/Area Number 16K20945
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental biology
Insect science
Research InstitutionUniversity of Tsukuba

Principal Investigator

Shimada Yuko  筑波大学, 生命領域学際研究センター, 助教 (30722699)

Co-Investigator(Renkei-kenkyūsha) Niwa Ryusuke  筑波大学, 生命環境系, 准教授 (60507945)
Research Collaborator Takemata Hitomi  筑波大学, 生命環境科学研究科
Katayama Minami  筑波大学, 生命環境科学研究科
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsAsobara japonica / 内部寄生蜂 / ショウジョウバエ / Drosophila melanogaster / 細胞死 / 成虫原基 / 免疫応答 / 感染 / キイロショウジョウバエ / ステロイドホルモン / 蛹化 / エクジステロイド / 自然免疫応答 / 発育調節
Outline of Final Research Achievements

An endoparasitic wasp, Asobara japonica, affects on the larval development of its host, Drosophila melanogaster. Upon infection, the host adult tissues, known as imaginal discs were degenerated. Overexpression of antiapototic gene p35 partially suppressed the successful parasitism, suggesting that the degeneration of imaginal discs is required for successful parasitism. To identify the bioactive molecule of A. japonica, we are trying to make the fractions of the whole body of wasp or the body fluid of host larvae by using the molecular weight-based filters.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During the Larval Development in Drosophila2017

    • Author(s)
      Enya S, Yamamoto C, Mizuno H, Esaki T, Lin H-K, Iga M, Morohashi K, Hirano T, Kataoka H, Masujima H, Shimada-Niwa Y, Niwa R
    • Journal Title

      Genetics

      Volume: 207 Issue: 4 Pages: 1519-1532

    • DOI

      10.1534/genetics.117.300391

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocols for visualizing steroidogenic organs and their interactive organs with immunostaining in the fruit fly Drosophila melanogaster.2017

    • Author(s)
      Imura E, Yoshinari Y, Shimada-Niwa Y, Niwa R
    • Journal Title

      Journal of Visualized Experiments

      Volume: 122 Issue: 122

    • DOI

      10.3791/55519

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ouija board: A transcription factor evolved for only one target in steroid hormone biosynthesis in the fruit fly Drosophila melanogaster.2016

    • Author(s)
      Niwa YS, Niwa R
    • Journal Title

      Transcription

      Volume: 7 Issue: 5 Pages: 196-202

    • DOI

      10.1080/21541264.2016.1210370

    • NAID

      120007128557

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptional regulation of insect steroid hormone biosynthesis and its role in controlling timing of molting and metamorphosis2016

    • Author(s)
      Yuko S. Niwa and Ryusuke Niwa
    • Journal Title

      Development, Growth & Differentiation

      Volume: 58 Issue: 1 Pages: 94-105

    • DOI

      10.1111/dgd.12248

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 栄養と発育をつなぐ神経内分泌機構の研究2017

    • Author(s)
      Yuko Shimada
    • Organizer
      日本分子生物学会第40回年会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploring a neuroendocrine link between feeding, wandering, and pupariation2016

    • Author(s)
      Yuko Shimada-Niwa
    • Organizer
      Janelia Conference “Behavioral Neurogenetics of Drosophila larva”
    • Place of Presentation
      Ashburn(アメリカ合衆国)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] Niwa+Shimada Lab, University of Tsukuba

    • URL

      https://sites.google.com/site/niwashimadalab/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 筑波大学丹羽研究室

    • URL

      http://niwa-lab.org

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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