| Project/Area Number |
16K20945
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
Insect science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Shimada Yuko 筑波大学, 生命領域学際研究センター, 助教 (30722699)
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| Co-Investigator(Renkei-kenkyūsha) |
Niwa Ryusuke 筑波大学, 生命環境系, 准教授 (60507945)
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| Research Collaborator |
Takemata Hitomi 筑波大学, 生命環境科学研究科
Katayama Minami 筑波大学, 生命環境科学研究科
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Asobara japonica / 内部寄生蜂 / ショウジョウバエ / Drosophila melanogaster / 細胞死 / 成虫原基 / 免疫応答 / 感染 / キイロショウジョウバエ / ステロイドホルモン / 蛹化 / エクジステロイド / 自然免疫応答 / 発育調節 |
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| Outline of Final Research Achievements |
An endoparasitic wasp, Asobara japonica, affects on the larval development of its host, Drosophila melanogaster. Upon infection, the host adult tissues, known as imaginal discs were degenerated. Overexpression of antiapototic gene p35 partially suppressed the successful parasitism, suggesting that the degeneration of imaginal discs is required for successful parasitism. To identify the bioactive molecule of A. japonica, we are trying to make the fractions of the whole body of wasp or the body fluid of host larvae by using the molecular weight-based filters.
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