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The study of functional analysis and therapeutic application of long-life neural stem cells derived from the adult hippocampus

Research Project

Project/Area Number 16K20957
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General pharmacology
General physiology
Research InstitutionChiba University

Principal Investigator

YOSHIOKA KENTO  千葉大学, 大学院医学研究院, 特任助教 (50758232)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords神経幹細胞 / p38α / ポリイミド多孔質膜 / 細胞・組織
Outline of Final Research Achievements

To know the molecular mechanism enabling the long-term maintenance of neural stem cells (NSCs) derived from the adult hippocampus and evaluate their possible therapeutic application, we conducted the following studies. (1) Based on the long-term maintenance of NSCs which might be promoted by p38α inhibition, the long-life NSCs labeled with fluorescent protein were transplanted into the cerebral cortex-injured mice. The transplanted cells were able to differentiate into neurons in the lesion area without tumorigenesis. (2) We have established a new method to maintain the activity of NSCs for a long time without either genetic disruption or pharmacological inhibition.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Genetic and Pharmacological Inhibition of p38α Improves Locomotor Recovery after Spinal Cord Injury.2017

    • Author(s)
      Umezawa H, Naito Y, Tanaka K, Yoshioka K, Suzuki K, Sudo T, Hagihara M, Hatano M, Tatsumi K, Kasuya Y.
    • Journal Title

      Front Pharmacol.

      Volume: 8 Pages: 72-72

    • DOI

      10.3389/fphar.2017.00072

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 成体海馬由来の神経幹細胞の大量培養法2017

    • Author(s)
      吉岡 健人、並木香奈、須藤龍彦、幡野雅彦、粕谷善俊
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎新聞文化ホール (長崎県長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 神経幹細胞の分化を抑制する方法、神経幹細胞を調整する方法、及び神経幹細胞を分化誘導する方法2017

    • Inventor(s)
      粕谷善俊、吉岡健人、萩原昌彦
    • Industrial Property Rights Holder
      粕谷善俊、吉岡健人、萩原昌彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-057635
    • Filing Date
      2017-03-23
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-12-27  

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