The study of functional analysis and therapeutic application of long-life neural stem cells derived from the adult hippocampus
| Project/Area Number |
16K20957
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
General physiology
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| Research Institution | Chiba University |
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Principal Investigator |
YOSHIOKA KENTO 千葉大学, 大学院医学研究院, 特任助教 (50758232)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経幹細胞 / p38α / ポリイミド多孔質膜 / 細胞・組織 |
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| Outline of Final Research Achievements |
To know the molecular mechanism enabling the long-term maintenance of neural stem cells (NSCs) derived from the adult hippocampus and evaluate their possible therapeutic application, we conducted the following studies. (1) Based on the long-term maintenance of NSCs which might be promoted by p38α inhibition, the long-life NSCs labeled with fluorescent protein were transplanted into the cerebral cortex-injured mice. The transplanted cells were able to differentiate into neurons in the lesion area without tumorigenesis. (2) We have established a new method to maintain the activity of NSCs for a long time without either genetic disruption or pharmacological inhibition.
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Report
(3 results)
Research Products
(3 results)
