Microfluidic formation of hydrogel microcapsules using coupling reaction in emulsion droplets
| Project/Area Number |
16K20985
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Reaction engineering/Process system
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | マイクロカプセル / ゲル粒子 / マイクロ流体デバイス / 水性二相 / 液滴内相分離 / 相分離 / ハイドロゲル |
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| Outline of Final Research Achievements |
We developed a simple continuous process to prepare tetra-arm poly(ethylene glycol) (tetra-PEG) hydrogel microcapsules consisting of a single aqueous core and a hydrogel shell by combining aqueous two phase system formation and end-coupling reaction of tetra-PEG macromonomers in aqueous droplets. Different from the conventional process, our process enables the production of monodisperse hydrogel microcapsules with controlled structures just by feeding solutions into a microfluidic device, without the use of any external stimuli for cross-linking reaction.
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Report
(3 results)
Research Products
(6 results)
