Research Project
Grant-in-Aid for Young Scientists (B)
Viral infection in perinatal period increases the risk of psychiatric disorders in the offspring. Polyinosinic-polycytidylic acid (polyI:C) induces strong immune reaction which mimic viral infection. Previous findings showed that interferon-induced transmembrane protein 3 (IFITM3) is a key molecule in polyI:C-induced neuronal impairment. It is unknown how IFITM3 mediates polyI:C-induced neuronal impairment. The purpose of this study is to understand the role of IFITM3 in polyI:C-dependent neuronal impairment. We identified Rab GTPase dissociation inhibitor as novel IFITM3-interacting protein by proteomic analysis. IFITM3 was colocalized with RabGDI in cultured astrocytes. We found that expression of IFITM3 increased the EEA1-poisitive vesicle size. We also found that forced expression of dominant negative Rab5 in astrocytes partially ameliorated polyI:C-indecd neuronal impairment. These results suggest that IFITM3 may mediate polyI:C-induced neruonal impairment through RabGDI.
All 2018 2017 2016
All Journal Article (4 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 4 results, Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)
Genes Brain Behav
Volume: 印刷中 Issue: 8
10.1111/gbb.12478
Glia
Volume: 66 Issue: 5 Pages: 1034-52
10.1002/glia.23299
J Neurochem.
Volume: - Issue: 1 Pages: 19-33
10.1111/jnc.14274
Biochem Biophys Res Commun.
Volume: 493 Issue: 4 Pages: 1384-1389
10.1016/j.bbrc.2017.09.159
