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Development of pharmacological treatment for delirium: analysis of cerebrospinal fluid and interventional study

Research Project

Project/Area Number 16K21082
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
General internal medicine(including psychosomatic medicine)
Research InstitutionNagoya University

Principal Investigator

Hirotaka Nakashima  名古屋大学, 医学部附属病院, 病院助教 (20759584)

Research Collaborator Kuzuya masafumi  
Umegaki hiroyuki  
Yanagawa madoka  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsオレキシン / 血漿 / せん妄 / 腎機能 / eGFR / クレアチニンクリアランス / 予測 / 髄液 / 血液 / インスリン / グルタミン酸
Outline of Final Research Achievements

We had changed the research plan to "Evaluation of the association between plasma orexin-A levels in patients with delirium." We enrolled 70 patients who were admitted to the geriatric ward, and we evaluated delirium and plasma orexin-A levels. As the result, plasma orexin-A levels did not have any association with delirium.
We obtained two additional results from this study. First, plasma orexin-A levels were negatively correlated with renal function. Second, preexisting impaired ADL(activities of daily living) and the severity of diseases on admission could strongly predict the development of delirium.

Academic Significance and Societal Importance of the Research Achievements

血漿中オレキシン濃度とせん妄には関連がなかった。オレキシンは主に脳から分泌されるため、オレキシンと脳との関係をより正確に把握するには、血液ではなく脳脊髄液を用いた研究が必要である。
腎機能の低下とともに体内のオレキシン濃度が高くなる可能性がある(血漿中オレキシンは腎臓を通して尿中へ排泄される可能性)。世界で血漿中オレキシン濃度を測定する研究が増えてきているが、今後は研究の計画や解釈に腎機能を考慮する必要がある。
入院時に簡便に入手できる情報からせん妄を予測することができるかもしれない。せん妄は予防が重要であるが、この結果をもとに、せん妄の起こる可能性の高い患者に集中的な予防策を講じることができる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Products Report
  • Research Products

    (4 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Plasma orexin-A levels in patients with delirium2019

    • Author(s)
      Hirotaka Nakashima, Hiroyuki Umigaki, Madoka Yanagawa, Hitoshi Komiya, Kazuhisa Watanabe, Masafumi Kuzuya
    • Journal Title

      Psychogeriatrics

      Volume: - Issue: 6 Pages: 628-630

    • DOI

      10.1111/psyg.12444

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma orexin-A-like immunoreactivity levels and renal function in patients in a geriatric ward2019

    • Author(s)
      Hirotaka Nakashima, Hiroyuki Umegaki, Madoka Yanagawa, Hitoshi Komiya, Kazuhisa Watanabe, Masafumi Kuzuya
    • Journal Title

      Peptides

      Volume: 118 Pages: 170092-170092

    • DOI

      10.1016/j.peptides.2019.170092

    • Related Report
      Products Report
    • Peer Reviewed
  • [Presentation] せん妄患者における血漿中オレキシン濃度2019

    • Author(s)
      中嶋宏貴、梅垣宏行、柳川まどか、小宮仁、渡邊一久、葛谷雅文
    • Organizer
      第61回日本老年医学会学術集会
    • Related Report
      Products Report
  • [Presentation] 入院時に容易に入手できる情報からせん妄を予測する2018

    • Author(s)
      中嶋宏貴、梅垣宏行、柳川まどか、小宮仁、渡邊一久、葛谷雅文
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2024-03-28  

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