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Involvement of signal transduction by chemical synapse in neuropathic pain mechanisms.

Research Project

Project/Area Number 16K21187
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Prosthodontics/ Dental materials science and
Research InstitutionOkayama University

Principal Investigator

Maruhama Kotaro  岡山大学, 医歯薬学総合研究科, 助教 (60712792)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsボツリヌス毒素 / 神経伝達物質 / 三叉神経 / 神経障害性疼痛 / SNAP-25 / 神経科学 / 解剖学 / 脳・神経 / 歯学
Outline of Final Research Achievements

Involvement of BoNT localization in the peripheral nervous system in abnormal orofacial pain sensations after peripheral nerve injury was investigated.It was revealed that BoNT might be cleaves the SNAP-25 that is a membrane protein of the nerve ending after the trigeminal nerve injury, suggesting that BoNT may function in the trigeminal ganglia and be involved in the suppression of neuropathic pain.

Academic Significance and Societal Importance of the Research Achievements

疼痛という感覚入力における情報伝達機構の解明やその治療法の開発は喫緊の課題である。本申請研究は、化学シナプスによる情報伝達を抑制する BoNTの効果を用いて、神経障害性疼痛の発症機構ならびに感覚入力における1次求心性ニューロンでの情報伝達機構の解明が目的とした。BoNTの機能発現部位が三叉神経系に存在する可能性が示唆されたことから、頭頸部の痛みにおけるBoNTの疼痛抑制発現メカニズムの解明、またその応用につながることから社会的意義は大きいと考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 末梢神経損傷後の脊髄後角ニューロンの興奮性における時間空間的変化2016

    • Author(s)
      寺山隆司,山本裕也,岸本宜子,田畑光康,丸濱功太郎,飯田征二,杉本朋貞
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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