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Viral etiology of suspected ebola virus disease cases in West Africa

Research Project

Project/Area Number 16K21234
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Virology
Research InstitutionNagasaki University

Principal Investigator

KUROSAKI Yohei  長崎大学, 熱帯医学研究所, 助教 (40415443)

Research Collaborator Magassouba N' Faly  ギニア国家出血熱対策プロジェクト, ウイルス診断部長
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsエボラウイルス病 / 西アフリカ / 感染疫学 / ウイルス / シークエンス / エボラウイルス / 疫学 / 分子系統 / 遺伝子解析 / 鑑別診断 / 感染症 / 熱性疾患 / 分子疫学
Outline of Final Research Achievements

The aim of this study was to determine the etiology of non-Ebola virus disease (EVD) cases, which showed EVD-like clinical signs, but were excluded viral infection by a laboratory testing, in the recent endemic of the disease in West Africa. In the collaboration with the National Donka Hospital in Guinea, we conducted screening detection of viruses which causes systematic febrile illness and malaria on the 71 samples from non-EVD cases. We detected dengue virus, enteroviruses, measles virus, and malaria positive cases in these samples, and determined the genotype of the detected viruses using partial or whole genome sequences by Sanger or next generation sequencing. These results suggested that these viruses and malaria caused clinical symptoms similar to EVD, and should be differentiated from EVD in clinical and laboratory diagnosis. Furthermore, these results suggested that these viral diseases have been endemic in Guinea.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Different effects of two mutations on the infectivity of Ebola virus glycoprotein in nine mammalian species2018

    • Author(s)
      Kurosaki, Y., Ueda, M.T., Nakano, Y., Yasuda, J., Koyanagi, Y., Sato, K. and Nakagawa, S.
    • Journal Title

      Journal of General Virology

      Volume: 99(2) Issue: 2 Pages: 181-186

    • DOI

      10.1099/jgv.0.000999

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] エボラウイルス西アフリカ流行株に見られたアミノ酸変異とその機能的影響2017

    • Author(s)
      黒崎陽平, 上田真保子, 中野雄介, 安田二朗, 小柳義夫, 佐藤佳, 中川草
    • Organizer
      第70 回 日本細菌学会九州支部総会・第54 回 日本ウイルス学会九州支部総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional mutations in spike glycoprotein of ebolaviruses associated with alterations in infection efficiency2017

    • Author(s)
      Kurosaki Y, Ueda MT, Izumi T, Nakano Y, Oloniniyi O, Yasuda J, Koyanagi Y, Sato K, Nakagawa S.
    • Organizer
      9th International Filovirus Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deployment of rapid and portable diagnostic test for field surveillance of Ebola virus disease in Guinea2016

    • Author(s)
      Yohei Kurosaki, N’Faly Magassouba, Olamide K. Oloniniyi, Mahamoud S. Cherif, Jiro Yasuda
    • Organizer
      International Meeting for Emerging Diseases and Surveillance
    • Place of Presentation
      オーストリア、ウィーン
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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