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Reduction of HbA1c levels by fucoxanthin on UCP1 gene polymorphism

Research Project

Project/Area Number 16K21251
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Metabolomics
Research InstitutionSapporo Medical University

Principal Investigator

Mikami Nana  札幌医科大学, 医学部, 助教 (80700278)

Research Collaborator Kokai Yasuo  札幌医科大学, 医学部・フロンティア医学研究所, 教授 (20178239)
Sohma Hitoshi  札幌医科大学, 医療人育成センター・教育開発研究部門, 教授 (70226702)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsUCP1遺伝子多型 / フコキサンチン / ヘモグロビンA1c / 栄養学 / 食品 / 遺伝子
Outline of Final Research Achievements

In our previous study, we showed 8-week fucoxanthin administration reduced HbA1c levels of healthy people especially in G/G allele carriers of UCP1 -3826A/G polymorphism. Because the carriers are known to be high risk population for onset of obesity and type 2 diabetes, we verified the Fx effects targeting on 120 people with prediabetes in this study. As a result, no significant differences were detected on HbA1c levels between UCP1 genotypes. These results suggest that Fx effects on UCP1 polymorphism may be associated with HbA1c distribution of target population (healthy or prediabetic) and outdoor temperature of trial period.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): a randomised controlled trial in normal-weight and obese Japanese adults2017

    • Author(s)
      Nana Mikami, Masashi Hosokawa, Kazuo Miyashita, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai
    • Journal Title

      Journal of Nutritional Science

      Volume: 6

    • DOI

      10.1017/jns.2017.1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Protocol for Human Serum Fucoxanthinol Quantitation using LC-MS/MS System2016

    • Author(s)
      Nana Mikami, Masashi Hosokawa, Masayuki Abe, Kazuo Miyashita, Hitoshi Sohma, Yasuo Kokai
    • Journal Title

      Journal of Nutritional Medicine and Diet Care

      Volume: 2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] UCP1遺伝子型に基づいたフコキサンチンによるヘモグロビンA1cの低下効果2018

    • Author(s)
      三上奈々・細川雅史・宮下和夫・相馬仁・小海康夫
    • Organizer
      第8回学際的脂質創生研究部会講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reduction of HbA1c levels by fucoxanthin on UCP1 Polymorphism in Japanese and its availability as tailored applications.2018

    • Author(s)
      Nana Mikami
    • Organizer
      Fucoxanthin Seminar, Cawthron Institute, Nelson, New Zealand
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] UCP1遺伝子多型に基づいたフコキサンチンによるヘモグロビンA1c低下効果2017

    • Author(s)
      三上奈々・細川雅史・宮下和夫・相馬仁・小海康夫
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Fucoxanthin Improves HbA1c in G/G Allele Carriers of UCP1 Polymorphism in Japanese: Rumoi Fucoxanthin Study2017

    • Author(s)
      Nana Mikami, Masashi Hosokawa, Kazuo Miyashita, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai
    • Organizer
      2017 AOCS Annual Meeting and Industry Showcases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域フィールドを活用した臨床研究の取り組みとフコキサンチンの健康機能性2017

    • Author(s)
      三上奈々
    • Organizer
      第29回夏期油脂・コレステロール研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 日本人を対象としたフコキサンチンのヘモグロビンA1c低下効果2016

    • Author(s)
      三上奈々・細川雅史・宮下和夫・相馬仁・小海康夫
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大(兵庫県西宮市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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