Research Project
Grant-in-Aid for Young Scientists (B)
Paired immunoglobulin-like receptor B (PirB) is a novel functional receptor for oligomerized beta-amyloid impairing cognitive and memory function in Alzheimer’s disease. I examined the regulation of the molecular function of PirB bound by oligomerized beta-amyloid. I found that LOTUS interacts with PirB. Furthermore, overexpression of LOTUS with PirB in COS7 cells blocked the binding of oligomerized beta-amyloid to PirB. Moreover, an antibody against PirB also interfered with the binding of oligomerized beta-amyloid to PirB overexpressed in COS7 cells. These data suggest that LOTUS or the antibody might inhibit the physiological function of PirB induced by oligomerized beta-amyloid.
All 2018 2017 2016
All Journal Article (7 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 7 results, Open Access: 7 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)
Journal of Neuroinflammation
Volume: 15 Issue: 1 Pages: 46-46
10.1186/s12974-018-1084-x
J Neurosci.
Volume: 38 Issue: 10 Pages: 2589-2604
10.1523/jneurosci.0953-17.2018
Trends Dev Biol.
Volume: 10 Pages: 41-47
Scientific Reports
Volume: 7 Issue: 1 Pages: 12119-12119
10.1038/s41598-017-12449-6
PLoS One
Volume: 12 Issue: 9 Pages: e0184258-e0184258
10.1371/journal.pone.0184258
Neuroscience
Volume: 356 Pages: 265-274
10.1016/j.neuroscience.2017.05.034
Sci Rep
Volume: 6 Issue: 1 Pages: 39586-39586
10.1038/srep39586