Possible mechanism of ballooned hepatocyte formation in non-alcoholic steatohepatitis
| Project/Area Number |
16K21307
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Metabolomics
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 非アルコール性脂肪肝炎 / NASH / 風船様肝細胞 / Ballooned hepatocyte / Hepatocyte ballooning / Autophagy / Fibrosis / 肝線維化 / Ballooning / Rubicon / カスパーゼ９ / オートファジー / 内科 / シグナル伝達 |
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| Outline of Final Research Achievements |
The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased. Non-alcoholic steatohepatitis (NASH) shows progression of liver fibrosis in NAFLD. NASH os characterized by presence of ballooned hepatocyte. We revealed that signaling of cell death and impaired autophagic process were associated with morphological and biochemical similarity of ballooned hepatocyte. We also found the presence of ballooned hepatocytes was a risk factor for the progression of liver fibrosis in clinical study. The present project demonstrated that ballooned hepatocyte might be therapeutic target of NASH.
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Report
(3 results)
Research Products
(7 results)
