| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
The purpose of this study is the development of new synthetic methodologies utilizing nucleophilic activation of carbonyl compounds by photo excitation. Acylsilanes have been known to undergo a 1,2-silylmigration to generate siloxycarbene intermediate which exhibits nucleophilicity at the carbene carbone under photo-irradiation conditions. We have developed reactions utilizing the photo-isomerization of acylsilanes. For instance, we found that photo-irradiation to a mixture of an acylsilane and an aldehyde in the presence of a Lewis acid catalyst afforded an α-siloxyketone in good yield.
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