| Project/Area Number |
16K21413
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
Emergency medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 麻酔 / microRNA / 虚血再灌流障害 / 肝臓 / 虚血再潅流障害 / 急性肝機能障害 / 遺伝子 |
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| Outline of Final Research Achievements |
Throughout the research period, we aim to identify (1) specific microRNA expression changes of hepatic ischemia reperfusion injury, (2) microRNA expression changes correlated with time-dependent change, (3) microRNA expression changes correlated with pathological disorder. During the first year, we made the research model and proceeded (1). It was difficult to identify candidate microRNA because the severity of ischemic-reperfusion injury was not stabilized. In the following year, we researched the correlations with time-dependent changes and pathological disorders with regard to the candidate microRNAs. However, none of the candidate microRNAs showed a good correlation, and it was not possible to determine markers useful for diagnosis.
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