| Project/Area Number |
16K21572
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied health science
Sports science
|
|---|
| Research Institution | Nagaoka National College of Technology |
|---|
Principal Investigator |
KAWAMOTO EMI 長岡工業高等専門学校, 物質工学科, 准教授 (40634514)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | AMPキナーゼ / 不活動 / インスリン抵抗性 / ルチン / ギプス固定 / 骨格筋 |
|---|
| Outline of Final Research Achievements |
Physical inactivity induces insulin resistance in skeletal muscle. In this study, we examined whether activation of AMP-activated protein kinase (AMPK) decreased in rat soleus muscle by using unilateral hindlimb immobilization model. As a result, no decrease in the phosphorylation level of AMP kinase, which indicates activation of AMP kinase, was observed in immobilized muscle. Also, in order to prevent inactivity-induced development of muscle insulin resistance, rutin which is a kind of plant-derived polyphenol was administered, but its preventive effect was not obtained.
|
