The effects of AMP-activated protein kinase on inactivity-induced insulin resistance

Research Project

Project/Area Number	16K21572
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Applied health science Sports science
Research Institution	Nagaoka National College of Technology
Principal Investigator	KAWAMOTO EMI 長岡工業高等専門学校, 物質工学科, 准教授 (40634514)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	AMPキナーゼ / 不活動 / インスリン抵抗性 / ルチン / ギプス固定 / 骨格筋
Outline of Final Research Achievements	Physical inactivity induces insulin resistance in skeletal muscle. In this study, we examined whether activation of AMP-activated protein kinase (AMPK) decreased in rat soleus muscle by using unilateral hindlimb immobilization model. As a result, no decrease in the phosphorylation level of AMP kinase, which indicates activation of AMP kinase, was observed in immobilized muscle. Also, in order to prevent inactivity-induced development of muscle insulin resistance, rutin which is a kind of plant-derived polyphenol was administered, but its preventive effect was not obtained.