Research Project
Grant-in-Aid for Young Scientists (B)
We established a novel murine model of cancer cachexia by implantation of human stomach cancer cell line 85As2 presenting anorexia, weight loss and low fat-free mass similar to those observed in patients. By using this model, we evaluated the effect of cachexia on cardiac function. At 2 weeks after implantation (pre-cachexia group), the mice began to show symptomatic cachexia; decreased body, skeletal muscle, and heart weight. The cachexia group (at 8 weeks after inoculation) developed severe cardiac atrophy in heart weight compared to controls. In addition, left ventricular ejection fraction was significantly decreased in pre-cachexia and cachexia group compared with age-matched controls. Histological and biochemical analyzes suggest that cardiac dysfunction may be caused by a pathway different from that of skeletal muscle atrophy. Further study is considered to be needed.
がんサバイバーの増加とともに、今まで顕在化していなかったがんサバイバーのQOLと心疾患についての関連性が近年指摘されている。がんサバイバーのフォローアップも含めた循環器系動態の把握、ならびにがん治療の有効性とがん治療に伴って起こる心機能障害を予防するために腫瘍循環器学という新しい学際領域が誕生した。本研究課題はこの腫瘍循環器学領域での研究の先駆けとなるものであり、がん悪液質によって心機能障害が起こること、さらにそのメカニズムの一端を明らかにすることができた。今後はがん悪液質で起こる心機能障害に対する予防薬や治療法についても詳細な検討を行っていきたいと考えている。
All 2018 2017 2016
All Journal Article (6 results) (of which Peer Reviewed: 6 results, Open Access: 4 results) Presentation (23 results) (of which Int'l Joint Research: 5 results)
J Pharmacol Sci
Volume: 137 Issue: 1 Pages: 67-75
10.1016/j.jphs.2018.04.002
Journal of Neuroendocrinology
Volume: 30 Issue: 9
10.1111/jne.12630
Frontiers in Nutrition
Volume: 5 Pages: 93-93
10.3389/fnut.2018.00093
Oncotarget
Volume: 9 Issue: 78 Pages: 34748-34764
10.18632/oncotarget.26190
Archives of Biochemistry and Biophysics
Volume: 637 Pages: 40-47
10.1016/j.abb.2017.11.009
Molecular Pain
Volume: 13 Pages: 1-9
10.1177/1744806917740030
