| Project/Area Number |
16K21647
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
Dermatology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Takai Erina 国立研究開発法人国立がん研究センター, 研究所, 外来研究員 (90723891)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 悪性黒色腫 / 次世代シーケンス / 血中遊離DNA / 癌 / ゲノム / cfDNA |
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| Outline of Final Research Achievements |
We investigated the utility of targeted deep sequencing of cell-free DNA (cfDNA) for monitoring of therapeutic response in melanoma patients. Plasma was obtained from melanoma patients across several time points during treatment and plasma cfDNA samples were subjected to targeted sequencing. We found that the changes of mutant cfDNA levels were associated with the treatment response or progression. Furthermore, it was suggested that tumor heterogeneity or clonal evolution might be reflected in cfDNA.
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