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Monitoring of therapeutic response by targeted sequencing of cell-free DNA in melanoma patients

Research Project

Project/Area Number 16K21647
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Dermatology
Research InstitutionNational Cancer Center Japan

Principal Investigator

Takai Erina  国立研究開発法人国立がん研究センター, 研究所, 外来研究員 (90723891)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性黒色腫 / 次世代シーケンス / 血中遊離DNA / 癌 / ゲノム / cfDNA
Outline of Final Research Achievements

We investigated the utility of targeted deep sequencing of cell-free DNA (cfDNA) for monitoring of therapeutic response in melanoma patients. Plasma was obtained from melanoma patients across several time points during treatment and plasma cfDNA samples were subjected to targeted sequencing. We found that the changes of mutant cfDNA levels were associated with the treatment response or progression. Furthermore, it was suggested that tumor heterogeneity or clonal evolution might be reflected in cfDNA.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] The mutational status of plasma cell-free DNA and their relevance to mutations in metastatic sites in an autopsy case of prostate cancer2017

    • Author(s)
      Erina Takai, Daichi Maeda, Yasushi Totoki, Hiromi Nakamura, Mamoru Kato, Takamitsu Inoue, Tomonori Habuchi, Akiteru Goto, Tatsuhiro Shibata, Shinichi Yachida
    • Organizer
      The 10th congress of Circulating Nucleic Acids in Plasma and Serum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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