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Study for internal models in motor learning control

Research Project

Project/Area Number 16K21649
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cognitive science
Rehabilitation science/Welfare engineering
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

HONDA Takeru  公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主任研究員 (20761307)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords運動制御 / 順モデル / 逆モデル / 脊髄小脳変性症 / プリズム適応課題 / 小脳 / 運動学習 / タンデム内部モデル / 内部モデル / 小脳患者 / 理論 / 神経生理学 / 新家内科学
Outline of Final Research Achievements

To clarify mechanism of internal models in the cerebellum during motor learning, we research conditions of updating internal models by experiments for human reaching movements in the prism adaptation task, built experimental formulas, and research distribution of clinical indexes which we developed about internal models of patients with cerebellar degenerations. We published a paper in an international journal (PNAS). We found (1) that there are both forward and inverse models in motor control and (2) that teaching signals generated by updating forward model due to error signals updates inverse model.

Academic Significance and Societal Importance of the Research Achievements

腕の運動制御に関して「小脳で学習される内部モデルはどのような入出力関係で何をモデル化しているのか」という長年の懸案に対して、腕がどこに動くのかという情報(順モデル)と動かす方法についての情報(逆モデル)の両方を学習しモデル化していることを明らかにした。また、順モデル、そして、逆モデルという順番で学習することを明らかにした。脊髄小脳変性症によって順モデルと逆モデルの両方の学習機能、または、逆モデルの学習機能のみ低下することを発見し、世界で初めて、脊髄小脳変性症についての学習機能低下の病態を明らかにした。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results) Remarks (3 results)

  • [Journal Article] Tandem internal models execute motor learning in the cerebellum2018

    • Author(s)
      Honda Takeru、Nagao Soichi、Hashimoto Yuji、Ishikawa Kinya、Yokota Takanori、Mizusawa Hidehiro、Ito Masao
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 28 Pages: 7428-7433

    • DOI

      10.1073/pnas.1716489115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 運動学習機能から見る熟練への道2019

    • Author(s)
      本多武尊
    • Organizer
      東京大学進化認知科学研究センター公開シンポジウム「熟練と脳認知機能」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Theory for explicit switch of cerebellar tandem internal models2019

    • Author(s)
      本多武尊
    • Organizer
      NEURO2019 (第42回日本神経科学大会、第62回日本神経化学会大会)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 正しい運動を実行するための 運動学習の仕組みの解明2018

    • Author(s)
      本多武尊
    • Organizer
      平成30年度第2回福祉保健局事業所長会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Tandem internal models fulfill precise motor learning2018

    • Author(s)
      Takeru Honda
    • Organizer
      第75回 藤原セミナー The Cerebellum as a CSN hub -from its evolution to therapeutic strategy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel clinical indexes for evaluating cerebellar internal models revealed by prism adaptation of human hand-reaching behavior2017

    • Author(s)
      Takeru Honda, Ken Matsumura, Youji Hashimoto, Kinya Ishikawa, Hidehiro Mizusawa, Soichi Nagao
    • Organizer
      the 8th International Symposium of he Society for Research on the Cerebellum and Ataxia (SRCA)
    • Place of Presentation
      University of Manitoba, Winnipeg, Manitoba, Canada
    • Year and Date
      2017-05-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tandem internal model predicts two types of cerebellar patients2017

    • Author(s)
      Takeru Honda
    • Organizer
      Society for Neuroscience (SfN 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel clinical indexes for evaluating cerebellar internal models revealed by prism adaptation of human hand-reaching behavior2017

    • Author(s)
      Takeru Honda, Ken Matsumura, Yuji Hashimoto, Kinya Ishikawa, Hidehiro Mizusawa and Soichi Nagao
    • Organizer
      8th International Symposium of the Society for Research on the Cerebellum (SRCA)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tandem Internal Models Fulfill Adaptive Motor Control2016

    • Author(s)
      Takeru Honda
    • Organizer
      RIKEN BSI Retreat 2016
    • Place of Presentation
      Miraikan, Tokyo, Japan
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 正しい運動を実行するための運動学習の仕組みの解明

    • URL

      http://www.igakuken.or.jp/topics/2018/0625.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 正しい運動を実行するための運動学習の仕組みの解明

    • URL

      http://www.igakuken.or.jp/project/to-tomin/to-pro25.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 正しい運動を実行するための運動学習の仕組みの解明

    • URL

      http://www.riken.jp/pr/press/2018/20180626_1/

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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