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Research on the neural mechanisms supporting multi-sensory fear memory

Research Project

Project/Area Number 16K21687
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cognitive science
Experimental psychology
Research InstitutionNational Institute of Information and Communications Technology

Principal Investigator

Koizumi Ai  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 研究員 (60588953)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords恐怖記憶 / モダリティー / 脳科学 / 感覚モダリティ / 脳機能 / 恐怖 / 知覚 / 7T fMRI / 皮質層 / モダリティ / 表情 / 7 Tesla fMRI / 高解像度 / 認知科学 / 実験系心理学
Outline of Final Research Achievements

This study examined the interaction between the visual cortex and pulvinar during visual perception of threat using fMRI. Specifically, we used fearful facial expressions as stimuli, as it is considered that humans are conditioned to be threatened by those expressions through evolution and/or experience. After the pilot with a typical 3T fMRI with a resolution of 3mm, we carried out an experiment with a high-resolution 7T fMRI at a resolution of 0.8mm. In addition, we conducted a pilot study targeting an olfactory modality, which extended the scope of study from a common visual modality to another less studied modality.

Academic Significance and Societal Importance of the Research Achievements

強い恐怖記憶は、心的外傷後ストレス障害(PTSD)の発症に繋がりうる。PTSDの発症を適切に予防して治療するためにも、恐怖記憶メカニズムの理解が不可欠である。しかしながら、現実の場面で遭遇するような、複数のモダリティーを対象とした恐怖記憶を題材とした研究はまだ少ない。また、人を対象とした研究では、侵襲的な計測が難しく、人の恐怖記憶形成メカニズムの理解の多くが、動物実験の結果を元に推測されている。本研究では複数の感覚モダリティーを対象としただけでなく、従来よりも3から4倍の空間解像度をもつ7T-fMRIを用いて非侵襲的に精緻なメカニズム検証に取り組み、その社会的・臨床的な意義は大きいと言える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] Maastricht University(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Maastricht University/Department of Cognitive Neuroscience(Netherlands)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] マーストリヒト大学(オランダ)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1)2018

    • Author(s)
      Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Maarten Vaessen, Beatrice de Gelder, Kaoru Amano
    • Journal Title

      BioRxiv

      Volume: October 2

    • DOI

      10.1101/431270

    • Related Report
      2018 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Presentation] Pulvinar modulates primary visual cortex in a laminar dependent manner during perception of fear2018

    • Author(s)
      Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Maarten Vaessen, Beatrice de Gelder, Kaoru Amano
    • Organizer
      The social & affective neuroscience society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] False percept of threat emerges from excessive activity in the V1 superficial layers2018

    • Author(s)
      Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Marteen Vanessen, Beatrice de Gelder, Kaoru Amano
    • Organizer
      The Social and Affective Neuroscience Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulvinar modulates primary visual cortex in a laminar dependent manner during perception of fear2017

    • Author(s)
      Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Marteen Vanessen, Beatrice de Gelder, Kaoru Amano
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulvinar modulate primary visual cortex in a laminar dependent manner during perception of fear - Preliminary study with 7-Tesla fMRI2017

    • Author(s)
      Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Marteen Vanessen, Beatrice de Gelder, Kaoru Amano
    • Organizer
      The Japan Neuroscience Society annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulvinar modulates primary visual cortex in a laminar dependent manner during perception of fear - Preliminary study with 7-Tesla fMRI2017

    • Author(s)
      小泉愛
    • Organizer
      第40回日本神経科学大会
    • Place of Presentation
      幕張メッセ国際展示場(千葉県、千葉市)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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