| Project/Area Number |
16K21714
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
Food science
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| Research Institution | Foundation for Biomedical Research and Innovation at Kobe |
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Principal Investigator |
Kobayashi Kanako 公益財団法人神戸医療産業都市推進機構, その他部局等, その他 (10724106)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | β-Klotho / FGF15 / 胎児発育 / 栄養学 / 子宮内発育遅延 / ノックアウトマウス |
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| Outline of Final Research Achievements |
β-Klotho/FGF15 system negatively regulates bile acid synthesis via transcriptional control of target molecules in adult mice. β-klotho and Fgf15 are expressed in embryonic stage, but whether they have functional association or not has been unclear. This study showed that β-Klotho expressed in yolk sac is important to receive FGF15 signal from embryo. Moreover, RNA-sequencing analysis revealed genes and metabolic processes regulated by β-Klotho/FGF15 system during embryonic stage in mice.
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| Academic Significance and Societal Importance of the Research Achievements |
低出生体重児は成人後に代謝疾患を発症するリスクが高いことが知られているが、胎児の発育を制御するメカニズムには不明な点が多い。本研究では、胎生期においてβ-Klotho/FGF15システムが制御する遺伝子と代謝経路を明らかにした。β-klotho欠損マウス胚とFgf15欠損マウス胚がいずれも発育抑制を呈することから、β-Klotho/FGF15システムの下流にある分子や代謝経路を解析することで胎児の発育制御に関わる新たなメカニズムが明らかになる可能性がある。
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