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Validation and construction of risk stratification system based on electronical health record information(Fostering Joint International Research)

Research Project

Project/Area Number 16KK0186
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Medical sociology
Research InstitutionKeio University

Principal Investigator

KOHSAKA Shun  慶應義塾大学, 医学部(信濃町), 講師 (30528659)

Project Period (FY) 2017 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Keywordsリスク評価 / 冠動脈疾患 / 心不全 / 医療の質 / 心房細動 / PRO / データベース / 虚血性心疾患 / カテーテルインターベンション / アウトカム
Outline of Final Research Achievements

For the present scientific project, we have started international collaborative work with Mid-American Heart Institute (MAHI) and Department of Cardiology, Stanford University in the United States. The collaborator in MAHI is Dr John A. Spertus, and we have compared the actual case-report from of the patient-based dataset on coronary artery disease (Keio interhospital cardiovascular studies [PCI] from Japan and National Cardiovascular Data Registry NCDR] CathPCI in the US). Risk models related to catheter-based therapeutics were constructed and validated. In addition, direct comparison of patient and procedural characteristics, along with its trend was investigated. With Stanford University, we collaborated with Dr Paul A. Heidenreich. Administrative datasets in VA and NY State was used for this collaborative research. The main aims was to assess quality improvement measures in each countries (e.g. 30-day readmission in acute heart failure, frail index, or mortality in PCI).

Academic Significance and Societal Importance of the Research Achievements

循環器疾患のリスク評価やその提示に関してはこれまで多くの観察研究や臨床研究で集積されたデータを基になされてきた。しかし、それぞれの研究がなされた国あるいは地域に特異的なものであったため、その国際的な仕様に関しては検証作業がこれまでなされてこなかった。我々は特に循環器疾患のリスク提示に関して作業を進め、特に冠動脈疾患の経皮的な治療(PCI)さらに心不全領域に関してどのように項目や統計的モデルの補正を行えば日米の二国間でリスク評価法を共有し、かつ電子カルテベースで応用できるか検証を行った。

Report

(2 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (7 results)

All 2020 2019 2018

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 2 results)

  • [Int'l Joint Research] Stanford University(米国)2018

    • Year and Date
      2018-10-01
    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Kansas,Mid-America Heart Institute(米国)2018

    • Year and Date
      2018-10-01
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Initial Invasive or Conservative Strategy for Stable Coronary Disease.2020

    • Author(s)
      Maron DJ, Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, Boden WE, Kohsaka S, Mavromichalis S, Kirby R, Jeffries NO, Harrell FE Jr, Rockhold FW, Broderick S, Ferguson TB Jr, Williams DO, Harrington RA, Stone GW, Rosenberg Y et al.; ISCHEMIA Research Group.
    • Journal Title

      N Engl J Med

      Volume: 382(15) Issue: 15 Pages: 1395-1407

    • DOI

      10.1056/nejmoa1915922

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Benefit and harm of intravenous vasodilators across the clinical profile spectrum in acute cardiogenic pulmonary oedema patients2020

    • Author(s)
      Shiraishi Yasuyuki、Kohsaka Shun、Katsuki Toshiomi、Harada Kazumasa、Miyazaki Tetsuro、Miyamoto Takamichi、Matsushita Kenichi、Iida Kiyoshi、Takei Makoto、Yamamoto Yoshiya、Shindo Akito et al.
    • Journal Title

      European Heart Journal: Acute Cardiovascular Care

      Volume: - Issue: 5 Pages: 448-458

    • DOI

      10.1177/2048872619891075

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kidney outcomes associated with use of SGLT2 inhibitors in real-world clinical practice (CVD-REAL 3): a multinational observational cohort study2020

    • Author(s)
      Heerspink Hiddo J L、Karasik Avraham、Thuresson Marcus、Melzer-Cohen Cheli、Chodick Gabriel、Khunti Kamlesh、Wilding John P H、Garcia Rodriguez Luis Alberto、Cea-Soriano Lucia、Kohsaka Shun、Nicolucci Antonio、Lucisano Giuseppe、Lin Fang-Ju、Wang Chih-Yuan、Wittbrodt Eric、Fenici Peter、Kosiborod Mikhail
    • Journal Title

      The Lancet Diabetes & Endocrinology

      Volume: 8 Issue: 1 Pages: 27-35

    • DOI

      10.1016/s2213-8587(19)30384-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association Between Current and Future Annual Hospital Percutaneous Coronary Intervention Mortality Rates2019

    • Author(s)
      Sandhu Alexander T.、Kohsaka Shun、Bhattacharya Jay、Fearon William F.、Harrington Robert A.、Heidenreich Paul A.
    • Journal Title

      JAMA Cardiology

      Volume: 4 Issue: 11 Pages: 1077-1077

    • DOI

      10.1001/jamacardio.2019.3221

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry2019

    • Author(s)
      Tani Hidenori、Sawano Mitsuaki、Numasawa Yohei、Kobayashi Yuhei、Suzuki Masahiro、Noma Shigetaka、Shiraishi Yasuyuki、Ueda Ikuko、Fukuda Keiichi、Kohsaka Shun
    • Journal Title

      Journal of Cardiology

      Volume: Epub ahead of print Issue: 6 Pages: 635-640

    • DOI

      10.1016/j.jjcc.2019.11.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed

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Published: 2017-03-15   Modified: 2021-02-19  

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