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Evaluation of longitudinal change in early glaucoma using big data(Fostering Joint International Research)

Research Project

Project/Area Number 16KK0208
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionSaitama Medical University

Principal Investigator

Shoji Takuhei  埼玉医科大学, 医学部, 講師 (70637058)

Research Collaborator Weinreb Robert N.  カリフォルニア大学サンディエゴ校, ハミルトン緑内障研究所, Distinguished Professor
Project Period (FY) 2016 – 2018
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords緑内障 / 光干渉断層計 / 光干渉断層血管撮影 / 縦断解析 / 光干渉断層計アンジオグラフィー / OCT / OCTA / 眼科学 / 解剖学 / 解析・評価 / 画像
Outline of Final Research Achievements

We performed longitudinal analysis of fundus photograh, intraocular pressure, corneal thickness, optical coherence tomography (OCT) data and visual fiield data accumulated for over 20 years in University of California at San Diego, and analysed factors related to glaucoma progression. Moreover, we perfirned cross-sectional and longitudinal analyzes of glaucoma early onset and structural changes, hemodynamic changes and functional changes using optical coherence tomography (OCTA) data accumulated from 2015.
We reported that not only the vascular density of radial peripapillary capillaries (RPCs) decreases, but also the macular vascular density associated with retinal ganglion cells decreases with the progress of glaucoma. Blood vessel density in the macular region was found to change over time in advanced glaucoma, suggesting a different progression process from structural change.

Academic Significance and Societal Importance of the Research Achievements

緑内障は慢性に進行する不可逆的変化であり、早期発見早期化量が重要であると考えられている。近年の画像機器の進歩により、緑内障進行に関連する、網膜神経節細胞や網膜神経線維層の形態変化が、緑内障の機能変化である視野障害に先行することが知られている。
緑内障は慢性変化のため、長期間にわたる経時的観察が必要であるが、国内で良質なデータベースを保有している施設は少なく、今回の共同研究により、長期経過の中でどのように緑内障初期変化が生じているのかを捉えることができたのは、社会的意義が大きいと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (31 results)

All 2019 2018 2017

All Int'l Joint Research (1 results) Journal Article (12 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 12 results,  Open Access: 2 results) Presentation (18 results) (of which Int'l Joint Research: 14 results,  Invited: 1 results)

  • [Int'l Joint Research] カリフォルニア大学サンディエゴ校(米国)2017

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma2019

    • Author(s)
      Hou Huiyuan、Moghimi Sasan、Zangwill Linda M.、Shoji Takuhei、Ghahari Elham、Penteado Rafaella C.、Akagi Tadamichi、Manalastas Patricia Isabel C.、Weinreb Robert N.
    • Journal Title

      American Journal of Ophthalmology

      Volume: 199 Pages: 120-132

    • DOI

      10.1016/j.ajo.2018.11.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of Macular and Circumpapillary Microvasculature with Visual Field Sensitivity in Advanced Glaucoma2019

    • Author(s)
      Ghahari Elham、Bowd Christopher、Zangwill Linda M.、Proudfoot James、Hasenstab Kyle A.、Hou Huiyuan、Penteado Rafaella C.、Manalastas Patricia Isabel C.、Moghimi Sasan、Shoji Takuhei、Christopher Mark、Yarmohammadi Adeleh、Weinreb Robert N.
    • Journal Title

      American Journal of Ophthalmology

      Volume: 印刷中 Pages: 51-61

    • DOI

      10.1016/j.ajo.2019.03.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Association between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes2018

    • Author(s)
      Manalastas PIC, Zangwill LM, Daga FB, Christopher MA, Saunders LJ, Shoji T, Akagi T, Penteado RC, Yarmohammadi A, Suh MH, Medeiros FA, Weinreb RN
    • Journal Title

      J Glaucoma

      Volume: 27 Issue: 3 Pages: 227-232

    • DOI

      10.1097/ijg.0000000000000862

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients2018

    • Author(s)
      Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders LJ, Hasenstab K, Ghahari E, Manalastas PIC, Akagi T, Christopher M, Penteado RC, Weinreb RN
    • Journal Title

      Am J Ophthalmol

      Volume: 189 Pages: 1-9

    • DOI

      10.1016/j.ajo.2018.02.002

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Macular Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects2018

    • Author(s)
      Ghahari Elham、Bowd Christopher、Zangwill Linda M.、Suh Min Hee、Shoji Takuhei、Hasenstab Kyle A.、Saunders Luke J.、Moghimi Sasan、Hou Huiyuan、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
    • Journal Title

      Journal of Glaucoma

      Volume: 27 Issue: 4 Pages: 342-349

    • DOI

      10.1097/ijg.0000000000000922

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes2018

    • Author(s)
      Hou Huiyuan、Moghimi Sasan、Zangwill Linda M.、Shoji Takuhei、Ghahari Elham、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
    • Journal Title

      American Journal of Ophthalmology

      Volume: 190 Pages: 69-77

    • DOI

      10.1016/j.ajo.2018.03.026

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma2018

    • Author(s)
      Penteado RC, Zangwill LM, Daga FB, Saunders LJ, Manalastas PIC, Shoji T, Akagi T, Christopher M, Yarmohammadi A, Moghimi S, Weinreb RN
    • Journal Title

      J Glaucoma

      Volume: 印刷中 Issue: 6 Pages: 1-1

    • DOI

      10.1097/ijg.0000000000000964

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Macular and Optic Nerve Head Vessel Density and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma2018

    • Author(s)
      Moghimi Sasan、Zangwill Linda M.、Penteado Rafaella C.、Hasenstab Kyle、Ghahari Elham、Hou Huiyuan、Christopher Mark、Yarmohammadi Adeleh、Manalastas Patricia Isabel C.、Shoji Takuhei、Bowd Christopher、Weinreb Robert N.
    • Journal Title

      Ophthalmology

      Volume: 125 Issue: 11 Pages: 1720-1728

    • DOI

      10.1016/j.ophtha.2018.05.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography2018

    • Author(s)
      Akagi Tadamichi、Zangwill Linda M.、Shoji Takuhei、Suh Min Hee、Saunders Luke J.、Yarmohammadi Adeleh、Manalastas Patricia Isabel C.、Penteado Rafaella C.、Weinreb Robert N.
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 8 Pages: e0201729-e0201729

    • DOI

      10.1371/journal.pone.0201729

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between Rates of Retinal Nerve Fiber Layer Thinning and Previous Disc Hemorrhage in Glaucoma2018

    • Author(s)
      Akagi Tadamichi、Saunders Luke J.、Shoji Takuhei、De Moraes Carlos Gustavo、Skaat Alon、Manalastas Patricia Isabel C.、Girkin Christopher A.、Liebmann Jeffrey M.、Zangwill Linda M.、Weinreb Robert N.
    • Journal Title

      Ophthalmology Glaucoma

      Volume: 1 Issue: 1 Pages: 23-31

    • DOI

      10.1016/j.ogla.2018.06.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes2017

    • Author(s)
      Manalastas PIC, Zangwill LM, Saunders LJ, Mansouri K, Belghith A, Suh MH, Yarmohammadi A, Penteado RC, Akagi T, Shoji T, Weinreb RN
    • Journal Title

      J Glaucoma

      Volume: 26 Issue: 10 Pages: 851-859

    • DOI

      10.1097/ijg.0000000000000768

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study2017

    • Author(s)
      Shoji T, Zangwill LM, Akagi T, Saunders LJ, Yarmohammadi A, Manalastas PIC, Penteado RC, Weinreb RN
    • Journal Title

      Am J Ophthalmol

      Volume: 182 Pages: 107-117

    • DOI

      10.1016/j.ajo.2017.07.011

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Comparison of structural and vessel density measurements in eyes with parafoveal scotoma and peripheral nasal step glaucoma2018

    • Author(s)
      Takuhei Shoji, Linda M. Zangwill, Tadamichi Akagi,, Luke J. Saunders, Adeleh Yarmohammadi, Patricia Isabel C. Manalastas, Rafaella Cleto Penteado, Huiyuan Hou, Elham Ghahari, Robert N. Weinreb
    • Organizer
      American Academy of Ophthalmology (AAO) 2017 Annual Meeting,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The African Descent and Glaucouma Evaluation Study : Racial Difference in the Rate of Retinal Nerve Fiber Layer Thinning in Eyes Suspected of Glaucouma : 5-Year Follow-Up2018

    • Author(s)
      Takuhei Shoji ,Tadamishi AKAGI, Luke J.SAUNDERS, Robert N.WEINREB, Linda M.ZANGWILL
    • Organizer
      33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Macular and peripapillary vascular dropout are associated with disease severity in advanced glaucoma2018

    • Author(s)
      Ghahari, Elham; Zangwill, Linda M; Bowd, C; Hasenstab, Kyle A; Hou, Huiyuan; Penteado, Rafaella C; Manalastas, Patricia Isabel C; Moghimi, S; Shoji, Takuhei; Li, Andrew, J; Nguyen, Khoa; Villatoro, George; Yarmohammadi, Adeleh; Weinreb, Robert N.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COMPARISON OF SUPERFICIAL VERSUS DEEP MACULA VESSEL DENSITY MEASUREMENTS IN NORMAL, GLAUCOMA SUSPECT, AND GLAUCOMA EYES2018

    • Author(s)
      Manalastas, Patricia Isabel C. Moghimi, Sasan; Zangwill, Linda M.; Christopher, Mark A.; Hasenstab, Kyle A.; Penteado, Rafaella C. Hou, HuiYuan. Shoji, Takuhei. Ghahari, Elham. Li, Andrew, J. Nguyen, Khoa. Villatoro, George. Yarmohammadi, Adeleh. Weinreb, Robert N.
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Progression of primary open angle glaucoma in diabetic and non-diabetic patients2018

    • Author(s)
      Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders L, Hasenstab K, Ghahari E, Manalatas PIC, Akagi T, Christopher M, Penteado R, Weinreb RN
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cross-sectional association between OCT angiography-measured optic nerve head and macular vessel densities and age in healthy eyes2018

    • Author(s)
      Nguyen K, Manalastas PI, Bowd C, Hasenstab K, Li A, Penteado R, Hou H, Shoji T, Villatoro G, Ghahari E, Moghimi S, Weinreb RN, Zangwill LM
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evalution of the Repeatability of Peripapillary Vascular Density With Swept-Source Optical Coherence Tomography Angiography2018

    • Author(s)
      Yuji Yoshikawa ,Junji KANNNO, Itaru KIMURA, Kei SHINODA, Takuhei SHOJI
    • Organizer
      33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative Assessment of Blood Vessel Density in Prelaminar Area With Swept-Source Optical Coherence Tomography Angiography in Healthy Subjects2018

    • Author(s)
      Kimitake Ozaki, Junji KANNNO, Itaru KIMURA, Kei SHINODA, Takuhei SHOJI, Yuji Yoshikawa
    • Organizer
      33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of structural and vessel density measurements in eyes with parafoveal scotoma and peripheral nasal step glaucoma2017

    • Author(s)
      Takuhei Shoji, Linda M. Zangwill, Tadamichi Akagi,, Luke J. Saunders, Adeleh Yarmohammadi, Patricia Isabel C. Manalastas, Rafaella Cleto Penteado, Huiyuan Hou, Elham Ghahari, Robert N. Weinreb
    • Organizer
      American Academy of Ophthalmology (AAO) 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 緑内障眼の乳頭出血発症時期の違いと網膜神経線維層菲薄化速度の関係2017

    • Author(s)
      赤木忠道、Robert N.Weinreb、庄司拓平、辻川孝明
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Comparison of structure and VD in POAG with parafoveal scotoma and nasal step2017

    • Author(s)
      庄司拓平、Luke J Saunders、赤木忠道、篠田啓、Linda M Zangwill、Robert N.Weinreb
    • Organizer
      第71回日本臨床眼科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Myopia and Glaucoma; Distortion of Lamina Cribrosa2017

    • Author(s)
      Takuhei Shoji
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Macular Vessel Density Loss is Increased in Primary Open Angle Glaucoma: A Longitudinal Study2017

    • Author(s)
      庄司拓平、Luke J Saunders, 赤木忠道、篠田啓、Linda M Zangeill, Robert N Wienreb
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Research-status Report
  • [Presentation] The rate of macular microvascular dropout is faster in glaucoma eyes than glaucoma suspect and healthy eyes: a longitudinal study2017

    • Author(s)
      Shoji T, Zangwill L, Akagi T, Saunders L, Yarmohammadi A, Manalastas PI, Penteado R, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The association between macula and optic nerve head optical coherence tomography angiography (OCT-A) vessel densities in glaucoma, glaucoma suspect and healthy eyes2017

    • Author(s)
      Manalastas P, Zangwill L, Saunders L, Daga F, Christopher M, Yarmohammadi A, Akagi T, Shoji T, Penteado R, Suh MH, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between optical coherence tomography and angiography macular vascular density measurements and central visual field damage2017

    • Author(s)
      Penteado R, Zanwill L, Daga F, Christopher M, Yarmohammadi A, Manalastas PI, Akagi T, Shoji T, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Vessel density is associated with visual field damage in advanced glaucoma eyes2017

    • Author(s)
      Yarmohammadi A, Zangwill L, Saunders L, Diniz-Filho A, Suh MH, Manalastas PI, Belghith A, Akagi T, Shoji T, Penteado R, Medeiros F, Weinreb R
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ellipsoid zone thickness measurements by high resolution mode-locked laser optical coherence tomography in healthy eyes2017

    • Author(s)
      Itaru Kimura, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Takuhei Shoji, Kei Shinoda, Makoto Araie, Shin Yoneya
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-03-15   Modified: 2020-03-30  

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