Elucidation of involvement of non-classical hydrogen bonding in transition states of asymmetric organocatalysis
| Project/Area Number |
16KT0164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Transition State Control
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| Research Institution | Sojo University (2018)
Kumamoto University (2016-2017) |
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Principal Investigator |
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| Project Period (FY) |
2016-07-19 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 有機分子触媒 / 遷移状態 / 非古典的水素結合 / 速度論的研究 / 量子化学計算 |
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| Outline of Final Research Achievements |
Although non-classical hydrogen bonding is pointed out as a factor to determine the superiority of the transition state of the asymmetric organocatalysis, almost no experimental verification has been made. So we have investigated the reaction system we developed in detail. As a result, several experimental results supporting the presence of non-classical hydrogen bonding were obtained. We also investigated kinetic and computational analysis of this reaction, and development of new catalysts.
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| Academic Significance and Societal Importance of the Research Achievements |
触媒反応の作用機序を深く理解することは、より高活性・高選択的な触媒を開発する上で重要である。本研究は、不斉有機触媒反応における非古典的水素結合の関与の実験的な検証を行なったものであり、さらに有用な触媒反応系の開発において一つの指針を与えるものと考えている。
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Report
(3 results)
Research Products
(12 results)
