• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Constructive understanding of the regulatory machinery of collective cell movement

Research Project

Project/Area Number 16KT0173
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Constructive Systems Biology
Research InstitutionKumamoto University

Principal Investigator

Nishiyama Koichi  熊本大学, 国際先端医学研究機構, 准教授 (80398221)

Research Collaborator YOKOKAWA Ryuji  
ALVARO Köhn-Luque  
Project Period (FY) 2016-07-19 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血管新生 / 血管内皮細胞 / 集団細胞運動 / 構成的解析システム / 集団的細胞運動 / 数理モデル / 細胞間作用
Outline of Final Research Achievements

Angiogenesis is a process to increase the vascular bed, in which vascular endothelial cells collectively move via cell-cell interactions and finally form dendrite structure. However, the underlying machinery is not fully understood. In the research project, we newly developed a reconstitution assay system, which enables us to dissect the machinery, including primary culture for murine endothelial cell and pericyte, cell-cell interaction assay for collective cell movement, in vitro and in silico angiogenesis model, and 4D image processing and quantification.

Academic Significance and Societal Importance of the Research Achievements

血管新生に限らず、我々生物の組織や器官は、細胞が寄り集まることで作られている。その際には、細胞同士が様々な相互作用を通して集団として移動する集団細胞運動が非常に重要である。本研究で確立した、血管新生の新たな解析システムは、血管新生における集団細胞運動の理解を進めることにとどまらず、生物一般で見られる集団細胞運動の理解やそれを解析するための基盤技術として幅広く科学界に貢献することが期待される。また、血管新生の理解を深めることは、すなわち、血管新生が関与する病気の理解やそれを標的とした治療法の開発等、医療技術の発展にも大きく貢献する。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] オスロ大学(ノルウェー)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ドレスデン工科大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ドレスデン工科大学(ドイツ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] オスロ大学(ノルウェー)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ドレスデン工科大学(ドイツ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] オスロ大学(ノルウェー)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells.2018

    • Author(s)
      Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O.
    • Journal Title

      Angiogenesis

      Volume: 21 Issue: 2 Pages: 415-423

    • DOI

      10.1007/s10456-018-9605-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of Collateral Source Characteristics With 3‐Dimensional Analysis Using Micro?X‐Ray Computed Tomography2018

    • Author(s)
      Arima Yuichiro、Hokimoto Seiji、Tabata Noriaki、Nakagawa Osamu、Oshima Asahi、Matsumoto Yosuke、Sato Takahiro、Mukunoki Toshifumi、Otani Jun、Ishii Masanobu、Uchikawa Michie、Yamamoto Eiichiro、Izumiya Yasuhiro、Kaikita Koichi、Ogawa Hisao、Nishiyama Koichi、Tsujita Kenichi
    • Journal Title

      Journal of the American Heart Association

      Volume: 7 Issue: 6

    • DOI

      10.1161/jaha.117.007800

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Reconstitution assay system for understanding angiogenic morphogenesiss: the morphogenetic function of pericascular pericytes2018

    • Author(s)
      Koichi Nishiyama
    • Organizer
      International Vascular Biology Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Endothelial angiogenic morphogenesis and the modifiers2018

    • Author(s)
      Koichi Nishiyama
    • Organizer
      KAIST-Kumamoto University joint symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 構成的アプローチによる血管新生における細胞移動の理解2018

    • Author(s)
      西山 功一
    • Organizer
      第91回日本生化学大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 血管内皮-ペリサイトの協奏による血管新生機構2018

    • Author(s)
      西山 功一
    • Organizer
      第124回日本解剖学会・全国学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 血管を新生する集団的内皮細胞運動の構成的理解2017

    • Author(s)
      西山 功一
    • Organizer
      定量生物学の会 第8回年会
    • Place of Presentation
      静岡
    • Year and Date
      2017-01-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Establishment of a reconstitution assay system using mouse primary vascular cells for the understanding of angiogenic morphogenesis2017

    • Author(s)
      Michie Uchikawa, Yuichiro Arima, Sanshiro Hanada, Akiyoshi Uemura, Yoshimi Yamaguchi, Yuji Nashimoto, Akiko Nakamasu, Ryuji Yokokawa, Takashi Miura, Koichi Nishiyama
    • Organizer
      2017 Angiogenesis Conference GRC
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血管内皮細胞動態を制御する自律的・非自律的メカニズム2016

    • Author(s)
      西山 功一
    • Organizer
      BIO-Basic Research Integrative Meeting on Ophthalmology
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Coordinated angiogenic movement of tip endothelial cell revealed by experiments combined with mathematical modeling2016

    • Author(s)
      Koichi Nishiyama
    • Organizer
      血管生物医学会シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] ’わかる・できる生命科学の数理モデルとシミュレーション’ ー血管を伸長する細胞メカニズム’2017

    • Author(s)
      西山功一、杉原圭
    • Total Pages
      3
    • Publisher
      羊土社
    • Related Report
      2016 Research-status Report
  • [Remarks] 西山研究室(熊本大学国際先端医学研究機構)

    • URL

      http://kumamoto-ircms-nishiyama.jp/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report

URL: 

Published: 2016-07-20   Modified: 2023-03-08  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi