Constructive understanding of the regulatory machinery of collective cell movement
| Project/Area Number |
16KT0173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Constructive Systems Biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Nishiyama Koichi 熊本大学, 国際先端医学研究機構, 准教授 (80398221)
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| Research Collaborator |
YOKOKAWA Ryuji
ALVARO Köhn-Luque
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| Project Period (FY) |
2016-07-19 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 血管新生 / 血管内皮細胞 / 集団細胞運動 / 構成的解析システム / 集団的細胞運動 / 数理モデル / 細胞間作用 |
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| Outline of Final Research Achievements |
Angiogenesis is a process to increase the vascular bed, in which vascular endothelial cells collectively move via cell-cell interactions and finally form dendrite structure. However, the underlying machinery is not fully understood. In the research project, we newly developed a reconstitution assay system, which enables us to dissect the machinery, including primary culture for murine endothelial cell and pericyte, cell-cell interaction assay for collective cell movement, in vitro and in silico angiogenesis model, and 4D image processing and quantification.
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| Academic Significance and Societal Importance of the Research Achievements |
血管新生に限らず、我々生物の組織や器官は、細胞が寄り集まることで作られている。その際には、細胞同士が様々な相互作用を通して集団として移動する集団細胞運動が非常に重要である。本研究で確立した、血管新生の新たな解析システムは、血管新生における集団細胞運動の理解を進めることにとどまらず、生物一般で見られる集団細胞運動の理解やそれを解析するための基盤技術として幅広く科学界に貢献することが期待される。また、血管新生の理解を深めることは、すなわち、血管新生が関与する病気の理解やそれを標的とした治療法の開発等、医療技術の発展にも大きく貢献する。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells.2018
Author(s)
Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O.
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Journal Title
Angiogenesis
Volume: 21
Pages: 415-423
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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