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Genetic approach to elucidate roles of stomach cancer related genes

Research Project

Project/Area Number 17013066
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

YAMAMOTO Ken  Kyushu University, 生体防御医学研究所, 准教授 (60274528)

Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥61,400,000 (Direct Cost: ¥61,400,000)
Fiscal Year 2009: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2008: ¥11,500,000 (Direct Cost: ¥11,500,000)
Fiscal Year 2007: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2006: ¥12,800,000 (Direct Cost: ¥12,800,000)
Fiscal Year 2005: ¥12,800,000 (Direct Cost: ¥12,800,000)
Keywordsがん / ゲノム / 遺伝子多型 / 相関解析 / 連鎖解析 / 細胞死 / リジンメチル化 / PCAF / SET9 / 転写 / 胃がん / STCH / リジンメチレーション / 発がん / SNP / LON / ゲノム構造異常 / ATM / 連鎖 / 相関 / 2番染色体長腕 / 21番染色体長腕
Research Abstract

Genome-wide linkage study followed by association analyses on candidate chromosomes revealed stomach cancer-related gene, STCH, on chromosome 21. We indicated that STCH localizes ER and is involved in apoptosis pathway. Somatic mutation was identified in STCH gene in stomach cancer. We demonstrated that the STCH mutation endows anti-apoptotic property to cells. We also identified novel chromosomal aberrations of stomach cancer which will be important targets in future research for better understanding of stomach cancer pathogenesis.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (35 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (19 results) (of which Peer Reviewed: 6 results) Presentation (11 results) Book (5 results)

  • [Journal Article] P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance2010

    • Author(s)
      Shiota M, Yokomizo A, Tada Y, Uchiumi T, Inokuchi J, Tatsugami K, Kuroiwa K, Yamamoto K, Seki N, Naito S
    • Journal Title

      Cancer Sience (in press)

    • NAID

      10027830401

    • Related Report
      2009 Final Research Report
  • [Journal Article] Multiple lysine methylation of PCAF by Set9 methyltransferase2009

    • Author(s)
      Masatsugu T, Yamamoto K
    • Journal Title

      Biochem Biophys Res Commun 381(1)

      Pages: 22-26

    • Related Report
      2009 Final Research Report
  • [Journal Article] Multiple lysine methylation of PCAF by Set9 methyltransferase2009

    • Author(s)
      Masatsugu T, et al.
    • Journal Title

      Biochem Biophys Res Commun 381

      Pages: 22-26

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple lysine methylation of PCAF by Set9 methyltransferase2009

    • Author(s)
      Masatsugu T, et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 381

      Pages: 22-26

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis2008

    • Author(s)
      Yamagata N, Furuno K, Sonoda M, Sugimura H, Yamamoto K
    • Journal Title

      Biochem Biophys Res Commun 376(3)

      Pages: 499-503

    • Related Report
      2009 Final Research Report
  • [Journal Article] Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis2008

    • Author(s)
      Yamagata N, et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 376

      Pages: 499-503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association analysis of glutathione-S-transferase P1 (GSTP1) polymorphism with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy2007

    • Author(s)
      Yokomizo A, Yamamoto K, Kinukawa N, Tsunoda T, Koga H, Naito S
    • Journal Title

      Int J Urol 14(6)

      Pages: 500-504

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence2007

    • Author(s)
      Shide K, Shimoda K, Kamezaki K, Kakumitsu H, Kumano T, Numata A, Ishikawa F, Takenaka K, Yamamoto K, Matsuda T, Harada M
    • Journal Title

      Leuk Res. 31(8)

      Pages: 1077-1084

    • Related Report
      2009 Final Research Report
  • [Journal Article] Association analysis of glutathione-S-transferase P1(GSTP1) polymorphis with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy.2007

    • Author(s)
      Yokomizo, A, et. al.
    • Journal Title

      Int. J. Urol. 14

      Pages: 500-504

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of hemophagocytic lymphohistiocytosis in Japan.2007

    • Author(s)
      Ishii, E., et. al.
    • Journal Title

      Int. J. Hematol. 86

      Pages: 58-65

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence.2007

    • Author(s)
      Shide, K., et. al.
    • Journal Title

      Leuk. Res. 31

      Pages: 1077-1084

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence.2007

    • Author(s)
      Shide K. et al.
    • Journal Title

      Leuk. Res. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro2006

    • Author(s)
      Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K
    • Journal Title

      Biochem Biophys Res Commun 345(3)

      Pages: 1051-1058

    • Related Report
      2009 Final Research Report
  • [Journal Article] Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.2006

    • Author(s)
      Furuno K. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 345

      Pages: 1051-1058

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population2005

    • Author(s)
      Aoki M, Yamamoto K, Ohyama S, Yamamura Y, Takenoshita S, Sugano K, Minamoto T, Kitajima M, Sugimura H, Shimada S, Noshiro H, Hiratsuka M, Sairenji M, Ninomiya I, Yano M, Uesaka K, Matsuno S, Maehara Y, Aikou T, Sasazuki T
    • Journal Title

      Biochem Biophys Res Commun 335(2)

      Pages: 566-574

    • Related Report
      2009 Final Research Report
  • [Journal Article] A full genome scan for gastric cancer2005

    • Author(s)
      Aoki M, Yamamura Y, Noshiro H, Sakai K, Yokota J, Kohno T, Tokino T, Ishida S, Ohyama S, Ninomiya I, Uesaka K, Kitajima M, Shimada S, Matsuno S, Yano M, Hiratsuka M, Sugimura H, Itoh F, Minamoto T, Maehara Y, Takenoshita S, Aikou T, Katai H, Yoshimura K, Takahashi T, Akagi K, Sairenji M, Yamamoto K, Sasazuki T
    • Journal Title

      J Med Genet 42(1)

      Pages: 83-87

    • Related Report
      2009 Final Research Report
  • [Journal Article] A full genome scan for gastric cancer.2005

    • Author(s)
      Aoki M.et al.
    • Journal Title

      J.Med.Genet. 42

      Pages: 83-87

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population.2005

    • Author(s)
      Aoki M.et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 335

      Pages: 566-574

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 全ゲノムを対象とした胃がん発症を規定する遺伝要因の探索2005

    • Author(s)
      山本 健
    • Journal Title

      福岡医学雑誌 96

      Pages: 25-33

    • NAID

      120002834536

    • Related Report
      2005 Annual Research Report
  • [Presentation] メチル化酵素Set9によるPCAF分子リジン残基のメチル化2009

    • Author(s)
      政次俊宏, 山本健, 宮崎耕治
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Final Research Report
  • [Presentation] PCAF acetyltransferase activity is regulated by Set9-mediated methylation2008

    • Author(s)
      T. Masatsugu, K. Yamamoto
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] PCAF acetyltransferase activity is regulated by Set9-mediated methvlation2008

    • Author(s)
      Masatsugu T, et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Illumina317KSNPアレイを用いた胃癌細胞染色体の遺伝子異常プロファイリング2007

    • Author(s)
      古野憲司, 菅野康吉, 山本健
    • Organizer
      日本人類遺伝学会第52回大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 胃癌感受性遺伝子STCHの発現解析2007

    • Author(s)
      山方伸茂, 山本健
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Illumina 317K SNPアレイを用いた胃癌細胞染色体の遺伝子異常プロファイリング2007

    • Author(s)
      古野 憲司
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2007 Annual Research Report
  • [Presentation] E2F6転写制御に関わるSUZ12-EZH2複合体2006

    • Author(s)
      政次俊宏, 山本健
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規小胞体局在分子STCHの機能解析2006

    • Author(s)
      山方伸茂, 山本健
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 罹患同胞対連鎖解析による胃がん発症関連遺伝子の探索2005

    • Author(s)
      山本健
    • Organizer
      第4回北陸ポストゲノム研究フォーラム
    • Place of Presentation
      金沢
    • Year and Date
      2005-09-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Genome-wide scan for gastric cancer by affected sibpair method2005

    • Author(s)
      M. Aoki, K. Yamamoto, T. Sasazuki
    • Organizer
      Human Genome Meeting 2005
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] 罹患同胞対全ゲノム連鎖解析による胃がん発症関連遺伝子の探索2005

    • Author(s)
      山本健
    • Organizer
      第11回日本家族性腫瘍学会学術集会ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Book] 大腸癌Frontier(大腸がんハイリスクと遺伝子多型)2009

    • Author(s)
      山本健
    • Related Report
      2009 Final Research Report
  • [Book] 医学のあゆみ(癌における大規模snp関連解析の現状)2008

    • Author(s)
      山本健
    • Related Report
      2009 Final Research Report
  • [Book] Cancer Frontier(全ゲノム相関解析と大腸癌発症関連遺伝子多型)2008

    • Author(s)
      山本健
    • Related Report
      2009 Final Research Report
  • [Book] 医学のあゆみ2008

    • Author(s)
      山本健
    • Publisher
      医歯薬出版
    • Related Report
      2008 Annual Research Report
  • [Book] 福岡医学雑誌(全ゲノムを対象とした胃がん発症を規定する遺伝要因の探索)2005

    • Author(s)
      山本健
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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